TREATMENT OF CHRONIC DISSEMINATED GEOTRICHUM-CAPITATUM INFECTION WITH HIGH CUMULATIVE DOSE OF COLLOIDAL AMPHOTERICIN-B AND ITRACONAZOLE IN A LEUKEMIA PATIENT

被引：15

作者：

COFRANCESCO, E

VIVIANI, MA

BOSCHETTI, C

TORTORANO, AM

BALZANI, A

CASTAGNONE, D

机构：

[1] CTR RIC CLIN FARMACOL & TERAPEUT,IST IGIENE & MED PREVENT,I-20122 MILAN,ITALY

[2] OSPED MAGGIORE,IST RICOVERO & CURA CARATTERE SCI,SERV RADIOL,MILAN,ITALY

来源：

MYCOSES | 1995年 / 38卷 / 9-10期

关键词：

GEOTRICHUM CAPITATUM; LEUKEMIA; DISSEMINATED INFECTION; GRANULOMATOUS INFECTION; ANTIMYCOTIC CHEMOTHERAPY; AMPHOTERICIN B LIPID FORMULATION; ITRACONAZOLE;

D O I：

10.1111/j.1439-0507.1995.tb00068.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

A case of disseminated granulomatous Geotrichum capitatum infection is reported. A young patient with blastic crisis of chronic myelogenous leukaemia developed septicaemia caused by G. capitatum in the post-chemotherapy aplastic phase. Subsequently, disseminated infection of the liver, spleen, pancreas and kidneys was observed. Treatment with high cumulative doses of a lipid formulation of amphotericin B (Amphocil(TM), 20.2 g in 11 weeks) and maintenance with itraconazole resolved clinical manifestations of G. capitatum granulomatous disseminated disease and controlled reactivation of the infection during the two subsequent courses of cytotoxic chemotherapy.

引用

页码：377 / 384

页数：8

共 25 条

[1] DISSEMINATED TRICHOSPORONOSIS - MEETING THE CHALLENGE [J].