INCREASED CEREBROSPINAL-FLUID TAU IN PATIENTS WITH ALZHEIMERS-DISEASE

被引：121

作者：

JENSEN, M ^{[1
]}

BASUN, H ^{[1
]}

LANNFELT, L ^{[1
]}

机构：

[1] HUDDINGE UNIV HOSP,KAROLINSKA INST,NOVUM KFC,DEPT CLIN NEUROSCI,GERIATR MED SECT,S-14186 HUDDINGE,SWEDEN

来源：

NEUROSCIENCE LETTERS | 1995年 / 186卷 / 2-3期

关键词：

TAU; ALZHEIMERS DISEASE; CEREBROSPINAL FLUID; AMYLOID PRECURSOR PROTEIN MUTATION;

D O I：

10.1016/0304-3940(95)11297-A

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

One of the pathological features in Alzheimer's disease (AD) is neurofibrillary tangles in the brain. The main constituent of tangles is the microtubuli-associated protein tau in a hyperphosphorylated state. Tau is also released into cerebrospinal fluid (CSF), and in this study we have used an enzyme linked immunosorbent assay to measure tau in CSF from AD and control cases. Our findings show that tau levels in AD cases are significantly elevated compared to healthy control individuals. We suggest that tau may serve as a biochemical marker of Alzheimer's disease.

引用

页码：189 / 191

页数：3

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