ENHANCED CELLULAR PROLIFERATIVE ACTIVITY AND CELL-DEATH IN CHRONIC THYROIDITIS AND THYROID PAPILLARY CARCINOMA

被引：53

作者：

OKAYASU, I

SAEGUSA, M

FUJIWARA, M

HARA, Y

ROSE, NR

机构：

[1] JAPANESE RED CROSS,MED CTR,DEPT PATHOL,SHIBUYA KU,TOKYO,JAPAN

[2] OHME MUNICIPAL GEN HOSP,DEPT INTERNAL MED,OHME,TOKYO,JAPAN

[3] JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT MOLEC MICROBIOL & IMMUNOL,BALTIMORE,MD 21218

来源：

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY | 1995年 / 121卷 / 12期

关键词：

THYROIDITIS; PAPILLARY CARCINOMA; CELL PROLIFERATION; KI-67; CELL DEATH; APOPTOSIS; BCL-2; CELLULARITY;

D O I：

10.1007/BF01213321

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

For the analysis of cellular proliferative activity and cell death in thyroid diseases, the Ki-67 labeling index, bcl-2 protein expression and cell death of follicular epithelia by immunohistochemistry and in situ DNA nick-end labeling methods were evaluated in normal thyroid tissues as well as in surgical specimens from cases of Hashimoto's disease (16 cases), focal lymphocytic thyroiditis (13 cases), Graves' disease (15 cases), follicular adenoma (20 cases) and papillary carcinoma (43 cases). Cellular proliferative activity and cell death were both enhanced in cases of thyroiditis, including Hashimoto's disease and focal lymphocytic thyroiditis. Thyroids from patients with follicular adenoma and papillary carcinoma also showed increased cellular proliferative activity and cell death. In addition, predominant high cellularity and partial loss of bcl-2 protein expression in papillary carcinoma suggested that the overgrowth and dedifferentiation were associated with malignancy.

引用

页码：746 / 752

页数：7

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