HEMOGLOBIN AVICENNA (BETA-47 (CD6) ASP-] ALA) - NEW ABNORMAL HEMOGLOBIN

被引：13

作者：

RAHBAR, S ^{[1
]}

NOZARI, G ^{[1
]}

ALA, F ^{[1
]}

机构：

[1] IRANIAN BLOOD TRANSFUS SERV, TEHRAN, IRAN

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1979年 / 576卷 / 02期

关键词：

Chain variant; Hemoglobin Avicenna; Hemoglobin D; Hemoglobinopathies;

D O I：

10.1016/0005-2795(79)90421-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In a survey for abnormal haemoglobin variants in voluntary blood donors in Iran, a new variant was found in a young male who presented no clinical symptoms. It had the same electrophoretic mobility as haemoglobin D in alkaline buffers. Separation of the constituent polypeptide chains in acid urea buffer revealed it to be different from haemoglobin D previously found among Iranians. Analysis of its structure demonstrated a substitution to alanine (β47 Asp → Ala) in the same residue as is involved in haemoglobin G-Copenhagen (β47 Asp → Asn). © 1979.

引用

页码：466 / 470

页数：5

共 14 条

[1] ABNORMAL HUMAN HAEMOGLOBINS - SEPARATION AND CHARACTERIZATION OF ALPHA AND BETA CHAINS BY CHROMATOGRAPHY AND DETERMINATION OF 2 NEW VARIANTS HB CHESAPEAKE AND HB J (BANGKOK) [J].