AN EPIDEMIOLOGIC APPROACH TO GENE-ENVIRONMENT INTERACTION

被引：141

作者：

OTTMAN, R

机构：

[1] COLUMBIA UNIV,DIV EPIDEMIOL,NEW YORK,NY 10032

[2] NEW YORK STATE PSYCHIAT INST & HOSP,EPIDEMIOL BRAIN DISORDERS RES,NEW YORK,NY 10032

来源：

GENETIC EPIDEMIOLOGY | 1990年 / 7卷 / 03期

关键词：

epidemiology; human genetics; risk;

D O I：

10.1002/gepi.1370070302

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

This paper illustrates how epidemiologic principles can be used to investigate relationships between genetic susceptibility and other risk factors for disease. Five plausible models are described for relationships between genetic and environmental effects, and an example of a simple mendelian disorder that fits each model is given. Each model leads to a different set of predictions about disease risk in individuals with the genetic susceptibility alone, the risk factor alone, both, or neither. The risk predictions for the different models are described, and research designs for testing them are discussed. Copyright © 1990 Wiley-Liss, Inc., A Wiley Company

引用

页码：177 / 185

页数：9

共 25 条

[1] BARON M, 1987, NATURE, V326, P287
[2] Beutler E, 1983, METABOLIC BASIS INHE, P1629
[3] BRINTON LA, 1982, J NATL CANCER I, V69, P817
[4] XERODERMA PIGMENTOSUM - BIOCHEMICAL AND GENETIC CHARACTERISTICS
CLEAVER, JE
BOOTSMA, D
[J]. ANNUAL REVIEW OF GENETICS, 1975, 9 : 19 - 38
[5] GADEK JE, 1983, METABOLIC BASIS INHE, P1450
[6] GO RCP, 1983, J NATL CANCER I, V71, P455
[7] Haldane J. B. S., 1946, ANN EUGENICS LOND, V13, P197
[8] KAPPAS A, 1983, METABOLIC BASIS INHE, P130
[9] Kelsey J L, 1979, Epidemiol Rev, V1, P74
[10] KHOURY MJ, 1988, AM J HUM GENET, V42, P89

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