INCREASE OF AUTO ANTI-PHOSPHATIDYLINOSITOL ANTIBODIES IN PLASMA OF FEMALE RATS DURING THE APPEARANCE OF DMBA-INDUCED MALIGNANT MAMMARY-TUMORS

被引：5

作者：

FAIDERBE, S

CHAGNAUD, JL

DIOLEZBOJDA, F

KERDELHUE, B

GEFFARD, M

机构：

[1] UNIV BORDEAUX 2,IMMUNOL & PATHOL LAB,INSERM,CJF 88-13,BP 66,146 RUE LEO SAIGNAT,F-33076 BORDEAUX,FRANCE

[2] INRA,CNRS,UNITE NEUROBIOL REPROD,F-78350 JOUY EN JOSAS,FRANCE

来源：

CANCER LETTERS | 1991年 / 57卷 / 01期

关键词：

PHOSPHATIDYLINOSITOL; DMBA; MAMMARY TUMOR; AUTOANTIBODY; SPECIFICITY; AVIDITY;

D O I：

10.1016/0304-3835(91)90057-O

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Using a lipid-adapted ELISA, antiphosphatidylinositol (PtdIns) antibodies (Ab) have been found in sera of cancer patients. With the same procedure, we have checked their possible raising in plasma of female rats during the appearance of 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary tumors. Twenty days after DMBA administration, the mean anti-PtdIns Ab level was already higher than that of control rats (oil). Immunochemical analysis of the anti-PtdIns Ab site showed a rather high Ab avidity (8 x 10(-9) M, at half-displacement) and high specificity for glyceryl phosphate inositol residues. Other phospholipids (PL) were not recognized by the anti-PtdIns Ab induced by malignant cell transformation.

引用

页码：15 / 19

页数：5

共 18 条

[1]

AVRAMEAS S, 1988, ISI ATLAS-IMMUNOL, P111

[2] INOSITOL TRISPHOSPHATE, A NOVEL 2ND MESSENGER IN CELLULAR SIGNAL TRANSDUCTION [J].