HUMAN PAPILLOMAVIRUSES, HERPES-SIMPLEX VIRUSES, AND THE RISK OF ORAL-CANCER IN MEN

被引:128
作者
MADEN, C
BECKMANN, AM
THOMAS, DB
MCKNIGHT, B
SHERMAN, KJ
ASHLEY, RL
COREY, L
DALING, JR
机构
[1] FRED HUTCHINSON CANC RES CTR, DIV PUBL HLTH SCI, SEATTLE, WA 98104 USA
[2] UNIV WASHINGTON, DEPT EPIDEMIOL, SEATTLE, WA 98195 USA
[3] UNIV WASHINGTON, DEPT BIOSTAT, SEATTLE, WA 98195 USA
[4] UNIV WASHINGTON, DEPT EPIDEMIOL, SEATTLE, WA 98195 USA
关键词
HERPES SIMPLEX; HOMOSEXUALITY; ORAL NEOPLASMS; PAPILLOMAVIRUSES; SEX BEHAVIOR; SEXUALLY TRANSMITTED DISEASES;
D O I
10.1093/oxfordjournals.aje.a116209
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
A population-based case-control study was conducted in western Washington state to examine the relations between infection with human papilloma viruses (HPV), herpes simplex viruses (HSV), and risk of oral squamous cell cancer in men. Interviews were completed on 131 oral cancer cases diagnosed between January 1985 and December 1989 and 136 controls frequency matched to cases on age and date of diagnosis who were obtained by random digit dialing. The risk for oral cancer among men with 30 or more sexual partners was 2.4 times that of men with four or fewer partners (95% confidence interval (CI) 1.0-5.9). Men who ever practiced oral sex had lower risk for oral cancer relative to men who never practiced oral sex (relative risk (RR) = 0.4, 95% CI 0.2-0.8). Analyses of exfoliated oral cavity cells for the presence of HPV-6 DNA with polymerase chain reaction revealed that men with an oral HPV-6 infection had 2.9 times the risk for oral cancer of noninfected men (95% CI 1.1-7.3), whereas men with an oral HPV-16 infection had 6.2 times the risk for oral cancer of noninfected men (crude RR = 6.2, 95% CI 0.7-52.2). Relative risks associated with serologically detected HSV-1 and HSV-2 infections were 0.8 (95% CI 0.3-1.7) and 1.8 (95% CI 0.7-4.6), respectively. The authors conclude that HPV-6 is associated with oral cancer. Although men infected with HPV-16 and HSV-2 were at elevated risk, these associations may have been due to chance. The role of specific sexual practices in the transmission of viruses to the oral cavity remains unclear.
引用
收藏
页码:1093 / 1102
页数:10
相关论文
共 29 条
  • [1] USE OF DENSITOMETRIC ANALYSIS FOR INTERPRETING HSV SEROLOGIES BASED ON WESTERN-BLOT
    ASHLEY, RL
    MILITONI, J
    [J]. JOURNAL OF VIROLOGICAL METHODS, 1987, 18 (2-3) : 159 - 168
  • [2] COMPARATIVE VIROLOGICAL STUDIES OF CONDYLOMATA ACUMINATA REVEAL A LACK OF DUAL INFECTIONS WITH HUMAN PAPILLOMAVIRUSES
    BECKMANN, AM
    SHERMAN, KJ
    MYERSON, D
    DALING, JR
    MCDOUGALL, JK
    GALLOWAY, DA
    [J]. JOURNAL OF INFECTIOUS DISEASES, 1991, 163 (02) : 393 - 396
  • [3] ANTIBODY-RESPONSE TO TYPE-COMMON AND TYPE-UNIQUE EPITOPES OF HERPES-SIMPLEX VIRUS POLYPEPTIDES
    BERNSTEIN, DI
    BRYSON, YJ
    LOVETT, MA
    [J]. JOURNAL OF MEDICAL VIROLOGY, 1985, 15 (03) : 251 - 263
  • [4] BLOT WJ, 1988, CANCER RES, V48, P3282
  • [5] Breslow NE, 1980, IARC SCI PUBLICATION, V1
  • [6] HIGH PREVALENCE OF HUMAN PAPILLOMAVIRUS INFECTION AND POSSIBLE ASSOCIATION WITH BETEL QUID CHEWING AND SMOKING IN ORAL EPIDERMOID CARCINOMAS IN TAIWAN
    CHANG, KW
    CHANG, CS
    LAI, KS
    CHOU, MJ
    CHOO, KB
    [J]. JOURNAL OF MEDICAL VIROLOGY, 1989, 28 (01) : 57 - 61
  • [7] CONDYLOMA ACUMINATUM IN ROCHESTER, MINN, 1950-1978 .1. EPIDEMIOLOGY AND CLINICAL-FEATURES
    CHUANG, TY
    PERRY, HO
    KURLAND, LT
    ILSTRUP, DM
    [J]. ARCHIVES OF DERMATOLOGY, 1984, 120 (04) : 469 - 475
  • [8] SEXUAL PRACTICES, SEXUALLY-TRANSMITTED DISEASES, AND THE INCIDENCE OF ANAL CANCER
    DALING, JR
    WEISS, NS
    HISLOP, TG
    MADEN, C
    COATES, RJ
    SHERMAN, KJ
    ASHLEY, RL
    BEAGRIE, M
    RYAN, JA
    COREY, L
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1987, 317 (16) : 973 - 977
  • [9] PAPILLOMAVIRUS DNA IN HUMAN TONGUE CARCINOMAS
    DEVILLIERS, EM
    WEIDAUER, H
    OTTO, H
    ZURHAUSEN, H
    [J]. INTERNATIONAL JOURNAL OF CANCER, 1985, 36 (05) : 575 - 578
  • [10] EGLIN RP, 1983, LANCET, V2, P766