EFFECT OF SIMVASTATIN ON LP(A) CONCENTRATIONS

被引:33
作者
HAFFNER, S
ORCHARD, T
STEIN, E
SCHMIDT, D
LABELLE, P
机构
[1] MERCK & CO INC, W POINT, PA 19486 USA
[2] UNIV TEXAS, HLTH SCI CTR, DEPT MED, DIV CLIN EPIDEMIOL, SAN ANTONIO, TX 78284 USA
[3] UNIV PITTSBURGH, SCH PUBL HLTH, DEPT EPIDEMIOL, PITTSBURGH, PA 15260 USA
[4] MED RES LABS, CINCINNATI, OH USA
[5] MED COLL WISCONSIN, DEPT MED, MILWAUKEE, WI 53226 USA
关键词
SIMVASTATIN; LP(A); LOW-DENSITY CHOLESTEROL;
D O I
10.1002/clc.4960180507
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The effect of HMG-CoA reductase inhibitors on Lp(a) concentrations is controversial, with some studies showing an increase and others showing no effect on Lp(a) concentrations. Many of these studies have been limited by small sample size and the lack of a prospective design. We evaluated the effect of four treatments: (1) placebo, (2) simvastatin 10 mg PO QPM, (3) simvastatin 20 mg PO QAM, and (4) simvastatin 20 mg PO QPM on Lp(a) concentrations in a prospective, randomized, controlled clinical trial of 24 weeks in 343 subjects in 28 clinical sites in the United States. Simvastatin was not associated with a change in Lp(a) concentrations relative to placebo. These results were not affected by controlling for race, initial Lp(a) level, or urinary albumin excretion. Simvastatin significantly reduced low-density lipoprotein (LDL) cholesterol levels (10 mg PO QPM: -27.6%; 20 mg PO QAM: -28.1%; and 20 mg PO QPM: -34.3%, all p<0.001). It was concluded that in a large, randomized, controlled trial, simvastatin does not affect Lp(a) levels but markedly lowers LDL cholesterol levels.
引用
收藏
页码:261 / 267
页数:7
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