EVIDENCE FOR LOW BRAIN PENETRATION BY THE H-1-RECEPTOR ANTAGONIST TEMELASTINE (SK-AND-F-93944)

被引:11
作者
CALCUTT, CR [1 ]
GANELLIN, CR [1 ]
JACKSON, B [1 ]
LEIGH, BK [1 ]
OWEN, DAA [1 ]
SMITH, IR [1 ]
机构
[1] SK&F RES LTD,THE FRYTHE,WELWYN AL6 9AR,HERTS,ENGLAND
关键词
D O I
10.1016/0014-2999(87)90206-8
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:65 / 74
页数:10
相关论文
共 23 条
[1]  
BOISSIER JR, 1964, ARCH INT PHARMACOD T, V147, P372
[2]   PHARMACOLOGICAL STUDIES WITH SK AND F-93944 (TEMELASTINE), A NOVEL HISTAMINE H-1-RECEPTOR ANTAGONIST WITH NEGLIGIBLE ABILITY TO PENETRATE THE CENTRAL-NERVOUS-SYSTEM [J].
BROWN, EA ;
GRIFFITHS, R ;
HARVEY, CA ;
OWEN, DAA .
BRITISH JOURNAL OF PHARMACOLOGY, 1986, 87 (03) :569-578
[3]   HETEROGENEITY OF HISTAMINE H1-RECEPTORS - SPECIES VARIATIONS IN [MEPYRAMINE-H-3 BINDING OF BRAIN MEMBRANES [J].
CHANG, RSL ;
TRAN, VT ;
SNYDER, SH .
JOURNAL OF NEUROCHEMISTRY, 1979, 32 (06) :1653-1663
[4]   ANTIHISTAMINIC EFFECT OF TERFENADINE - A NEW PIPERIDINE-TYPE ANTIHISTAMINE [J].
CHENG, HC ;
WOODWARD, JK .
DRUG DEVELOPMENT RESEARCH, 1982, 2 (02) :181-196
[5]   HISTAMINE H1-AGONIST POTENTIATION OF ADENOSINE-STIMULATED CYCLIC-AMP ACCUMULATION IN SLICES OF GUINEA-PIG CEREBRAL-CORTEX - COMPARISON OF RESPONSE AND BINDING PARAMETERS [J].
DAUM, PR ;
HILL, SJ ;
YOUNG, JM .
BRITISH JOURNAL OF PHARMACOLOGY, 1982, 77 (02) :347-357
[6]  
DELEAN A, 1978, AM J PHYSL, V235, pE102
[7]   HISTAMINE H1-RECEPTORS LABELED INVIVO - ANTI-DEPRESSANT AND ANTIHISTAMINE INTERACTIONS [J].
DIFFLEY, D ;
TRAN, VT ;
SNYDER, SH .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1980, 64 (2-3) :177-181
[8]   STUDIES ON EFFECTS OF HISTAMINERGIC AGENTS ON SEIZURE SUSCEPTIBILITY IN MICE [J].
GERALD, MC ;
RICHTER, NA .
PSYCHOPHARMACOLOGIA, 1976, 46 (03) :277-282
[9]  
HEINRICH MAX A., 1953, ARCH INTERNATL PHARMACODYN ET THER, V92, P444
[10]   HISTAMINE H1-RECEPTORS IN THE BRAIN OF THE GUINEA-PIG AND THE RAT - DIFFERENCES IN LIGAND-BINDING PROPERTIES AND REGIONAL DISTRIBUTION [J].
HILL, SJ ;
YOUNG, JM .
BRITISH JOURNAL OF PHARMACOLOGY, 1980, 68 (04) :687-696