PHOSPHOLIPASE-C MEDIATED HYDROLYSIS OF PHOSPHATIDYLCHOLINE IS AN IMPORTANT STEP IN PDGF-STIMULATED DNA-SYNTHESIS

被引：168

作者：

LARRODERA, P ^{[1
]}

CORNET, ME ^{[1
]}

DIAZMECO, MT ^{[1
]}

LOPEZBARAHONA, M ^{[1
]}

DIAZLAVIADA, I ^{[1
]}

GUDDAL, PH ^{[1
]}

JOHANSEN, T ^{[1
]}

MOSCAT, J ^{[1
]}

机构：

[1] UNIV TROMSO,INST MED BIOL,N-9001 TROMSO,NORWAY

来源：

CELL | 1990年 / 61卷 / 06期

关键词：

D O I：

10.1016/0092-8674(90)90074-O

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent evidence suggests the involvement of phosphatidylcholine (PC) hydrolysis both in the control of normal cell growth and in transformation. We show here that the simple exogenous addition of Bacillus cereus PC-hydrolyzing phospholipase C (PC-PLC) is sufficient to elicit a potent mitogenic response in Swiss 3T3 fibroblasts by a mechanism that is independent of protein kinase C. Our results on the additivity and synergism between B. cereus PC-PLC, PDGF, and insulin in the mitogenic response indicate that this novel phospholipid degradative pathway may be important in the mitogenic signaling cascade activated by PDGF. © 1990.

引用

页码：1113 / 1120

页数：8

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