PROGNOSIS OF IDIOPATHIC PULMONARY FIBROSIS IN PATIENTS WITH MUCOUS HYPERSECRETION

被引：27

作者：

HIWATARI, N ^{[1
]}

SHIMURA, S ^{[1
]}

SASAKI, T ^{[1
]}

AIKAWA, T ^{[1
]}

ANDO, Y ^{[1
]}

ISHIHARA, H ^{[1
]}

SEKIZAWA, K ^{[1
]}

SASAKI, H ^{[1
]}

TAKISHIMA, T ^{[1
]}

机构：

[1] TOHOKU UNIV,SCH MED,DEPT INTERNAL MED 1,1-1 SEIRYO MACHI,AOBA KU,SENDAI,MIYAGI 980,JAPAN

来源：

AMERICAN REVIEW OF RESPIRATORY DISEASE | 1991年 / 143卷 / 01期

关键词：

D O I：

10.1164/ajrccm/143.1.182

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

In order to determine the prognosis of patients with chronic idiopathic pulmonary fibrosis (IPF), we evaluated clinical, laboratory, and bronchoalveolar lavage (BAL) data at the onset of IPF in 25 patients who survived beyond 1 yr (nine women and 16 men, 59 +/- 3 yr of age, mean +/- SE). When the patients were divided into two groups according to whether they had or did not have mucous hypersecretion, 11 patients with hypersecretion (Group A) had a poorer survival rate (6 yr) than did 14 patients without hypersecretion (Group B) (10 yr) (p < 0.01). Further, there was a significant negative correlation between sputum volume and the duration of survival in 25 patients (r = 0.55, p < 0.01). Before glucocorticold treatment, we also found significantly larger numbers of neutrophils (17%) and eosinophils (5%) in differential cell counts of bronchoalveolar lavage fluid (BALF) in Group A than in Group B (neutrophils, 1%; eosinophils, 0.6%) (p < 0.05 each). Chest radiographic findings and other laboratory data including pulmonary function tests did not correlate with the survival rate. These findings suggest that mucous hypersecretion as well as neutrophils and eosinophils in BALF are among the determinants of prognosis in patients with chronic IPF.

引用

页码：182 / 185

页数：4

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