TOXOPLASMA SEROLOGY, PARASITEMIA AND ANTIGENEMIA IN PATIENTS AT RISK FOR TOXOPLASMIC ENCEPHALITIS

被引：30

作者：

DANNEMANN, BR

ISRAELSKI, DM

LEOUNG, GS

MCGRAW, T

MILLS, J

REMINGTON, JS

机构：

[1] PALO ALTO MED FDN,RES INST,860 BRYANT ST,PALO ALTO,CA 94301

[2] STANFORD UNIV,SCH MED,DIV INFECT DIS,PALO ALTO,CA 94304

[3] SAN FRANCISCO GEN HOSP,DIV INFECT DIS,SAN FRANCISCO,CA 94110

[4] SAN FRANCISCO GEN HOSP,AIDS PROGRAM,SAN FRANCISCO,CA 94110

[5] UNIV CALIF DAVIS,CALIF PRIMATE INST,DAVIS,CA 95616

来源：

AIDS | 1991年 / 5卷 / 11期

关键词：

TOXOPLASMIC ENCEPHALITIS; AIDS; OPPORTUNISTIC INFECTION; SEROLOGY; PARASITEMIA; ANTIGENEMIA; PREVALENCE;

D O I：

10.1097/00002030-199111000-00013

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In order to further characterize the pathogenesis of Toxoplasma gondii infection in patients with AIDS and AIDS-related complex (ARC), a cohort of HIV- and Toxoplasma-infected individuals were identified and prospectively followed. Four hundred and 10 HIV-infected individuals followed in the San Francisco General Hospital AIDS Clinic were screened for antibodies to Toxoplasma between November 1986 and November 1988. Of the 67 (16%) individuals seropositive for Toxoplasma antibodies, 33 (49%) were followed monthly for a mean duration of 7.5 months. One hundred and 11 follow-up blood samples were obtained in order to determine Toxoplasma serology and the incidence of parasitemia. In general, Toxoplasma immunoglobulin (Ig) G antibodies remained stable over time. Detection of Toxoplasma antigenemia and parasitemia was uniformly negative, including those specimens obtained from two individuals within 45 days of their developing toxoplasmic encephalitis.

引用

页码：1363 / 1365

页数：3

共 18 条

[1] IMMUNOHISTOLOGICAL STUDY OF THE ANATOMIC RELATIONSHIP OF TOXOPLASMA ANTIGENS TO THE INFLAMMATORY RESPONSE IN THE BRAINS OF MICE CHRONICALLY INFECTED WITH TOXOPLASMA-GONDII [J].