OCCURRENCE OF CARBAMOYL-N-HYDROXY DERIVATIVES OF SAXITOXIN AND NEOSAXITOXIN IN A XANTHID CRAB ZOSIMUS-AENEUS

被引：48

作者：

ARAKAWA, O

NOGUCHI, T

SHIDA, Y

ONOUE, Y

机构：

[1] TOKYO COLL PHARM,HACHIOJI,TOKYO 19203,JAPAN

[2] UNIV TOKYO,FAC AGR,MARINE BIOCHEM LAB,BUNKYO KU,TOKYO,TOKYO 113,JAPAN

来源：

TOXICON | 1994年 / 32卷 / 02期

关键词：

D O I：

10.1016/0041-0101(94)90106-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Two novel paralytic toxins were isolated from toxic specimens of a xanthid crab Zosimus aeneus inhabiting Ishigaki Island, Okinawa. The structures of two of these were deduced to be carbamoyl-N-hydroxysaxitoxin and carbamoyl-N-hydroxyneosaxitoxin based on electrophoresis, high performance liquid chromatography, electrospray ionization mass spectrometry, H-1 NMR, C-13 NMR and conversion experiments. They showed specific toxicities of 1700 and 1400 mouse units per mg on i.p. injection into mice.

引用

页码：175 / 183

页数：9

共 21 条

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