PHYSICAL MAPPING OF 38 HIGHLY INFORMATIVE GENETIC-MARKERS TO 10 INTERVALS OF CHROMOSOME-11Q - INTEGRATION OF THE PHYSICAL AND GENETIC MAPS

被引：3

作者：

HUNT, D

VANHEYNINGEN, V

JONES, C

MCCONVILLE, C

BENHAM, FJ

机构：

[1] MRC,HUMAN BIOCHEM GENET UNIT,LONDON NW1 2HE,ENGLAND

[2] WESTERN GEN HOSP,MRC,HUMAN GENET UNIT,EDINBURGH EH4 2XU,SCOTLAND

[3] ELEANOR ROOSEVELT INST,DENVER,CO 80206

[4] UNIV BIRMINGHAM,DEPT CANC STUDIES,CRC LABS,BIRMINGHAM B15 2TS,W MIDLANDS,ENGLAND

来源：

ANNALS OF HUMAN GENETICS | 1994年 / 58卷

基金：

英国医学研究理事会;

关键词：

D O I：

10.1111/j.1469-1809.1994.tb01877.x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A large number of highly polymorphic microsatellite markers particularly suitable for linkage analysis have recently been developed. In order to facilitate integration of the genetic maps of chromosome 11q generated using these types of markers with the physical maps of 11q currently being assembled, we have regionally assigned the Genethon markers and the 11q designated index plus other commonly used polymorphic markers to ten physical intervals of 11q. These intervals are defined by translocation breakpoints immortalized in somatic cell hybrid lines and can therefore serve as readily accessible and stable landmarks for detailed map integration and facilitate the derivation and placement of new markers and cloned contigs.

引用

页码：81 / 85

页数：5

共 15 条

[1] ISOLATION OF 1001 NEW MARKERS FROM HUMAN CHROMOSOME-11, EXCLUDING THE REGION OF 11P13-P15.5, AND THEIR SUBLOCALIZATION BY A NEW SERIES OF RADIATION-REDUCED SOMATIC-CELL HYBRIDS [J].