MICROWAVE-INDUCED ORGANIC-REACTIONS OF BILE-ACIDS - ESTERIFICATION, DEFORMYLATION AND DEACETYLATION USING MILD REAGENTS

被引：29

作者：

DAYAL, B ^{[1
]}

RAO, K ^{[1
]}

SALEN, G ^{[1
]}

机构：

[1] UNIV MED & DENT NEW JERSEY,NEW JERSEY MED SCH,DEPT MED,NEWARK,NJ 07103

来源：

STEROIDS | 1995年 / 60卷 / 06期

关键词：

MICROWAVE; BILE ACIDS; ESTERIFICATION; DEFORMYLATION; DEACETYLATION; METHANESULFONIC ACID METHANOL; PARA-TOLUENE SULFONIC ACID METHANOL;

D O I：

10.1016/0039-128X(95)00004-A

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An efficient and convenient procedure for the esterification, deformylation, and deacetylation of bile acids is described. This is achieved by the addition of a catalytic amount of methanesulfonic acid or para-toluene sulfonic acid to a solution of bile acid in methanol in the domestic microwave oven. All these reactions were completed in the microwave oven within 1-3 min at 60% power (390 W) and the desired bile acids, namely trihydroxy-5 beta-cholestanoic acid, (23R)-3 alpha,7 alpha,23-trihydroxy-5 beta-cholan-24-oic acid, ursocholic acid and 7-ketolithocholic acid were isolated in 86-94% yield.

引用

页码：453 / 457

页数：5

共 18 条

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