ANTI-PROLIFERATIVE PROPERTIES OF DL-ALPHA-DIFLUOROMETHYL ORNITHINE IN CULTURED-CELLS - CONSEQUENCE OF IRREVERSIBLE INHIBITION OF ORNITHINE DECARBOXYLASE

被引：473

作者：

MAMONT, PS

DUCHESNE, MC

GROVE, J

BEY, P

机构：

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1978年 / 81卷 / 01期

关键词：

D O I：

10.1016/0006-291X(78)91630-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：58 / 66

页数：9

共 16 条

[1] INHIBITORS OF POLYAMINE BIOSYNTHESIS .1. ALPHA-METHYL-(+/-)-ORNITHINE, AN INHIBITOR OF ORNITHINE DECARBOXYLASE [J].

ABDELMONEM, MM ;

NEWTON, NE ;

WEEKS, CE .

JOURNAL OF MEDICINAL CHEMISTRY, 1974, 17 (04) :447-451

[2] FLUOROMETRIC ASSAY OF PROTEINS IN NANOGRAM RANGE [J].

BOHLEN, P ;

STEIN, S ;

DAIRMAN, W ;

UDENFRIEND, S .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1973, 155 (01) :213-220

[3] POSSIBLE INVOLVEMENT OF POLYAMINES IN INITIATION OF DNA-SYNTHESIS BY HUMAN WI-38 AND MOUSE BALB-3T3 CELLS [J].

BOYNTON, AL ;

WHITFIELD, JF ;

ISAACS, RJ .

JOURNAL OF CELLULAR PHYSIOLOGY, 1976, 89 (03) :481-488

[4] INCREASED CELLULAR LEVELS OF SPERMIDINE OR SPERMINE ARE REQUIRED FOR OPTIMAL DNA-SYNTHESIS IN LYMPHOCYTES ACTIVATED BY CONCANAVALIN A [J].

FILLINGAME, RH ;

JORSTAD, CM ;

MORRIS, DR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1975, 72 (10) :4042-4045

[5] EFFECT OF "METHYLGLYOXAL-BIS(GUANYLHYDRAZONE), AN INHIBITOR OF SPERMIDINE AND SPERMINE SYNTHESIS, ON CELL-CYCLE TRAVERSE [J].

HEBY, O ;

MARTON, LJ ;

WILSON, CB ;

GRAY, JW .

EUROPEAN JOURNAL OF CANCER, 1977, 13 (09) :1009-1017

[6]

HERSHKO A, 1971, J BIOL CHEM, V246, P710

[7] DNA-SYNTHESIS IN HELA-CELLS AND ISOLATED-NUCLEI AFTER TREATMENT WITH AN INHIBITOR OF SPERMIDINE SYNTHESIS, METHYL GLYOXAL BIS(GUANYLHYDRAZONE) [J].

KROKAN, H ;

ERIKSEN, A .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1977, 72 (03) :501-508

[8] ALPHA-METHYL ORNITHINE, A POTENT COMPETITIVE INHIBITOR OF ORNITHINE DECARBOXYLASE, BLOCKS PROLIFERATION OF RAT HEPATOMA-CELLS IN CULTURE [J].

MAMONT, PS ;

BOHLEN, P ;

MCCANN, PP ;

BEY, P ;

SCHUBER, F ;

TARDIF, C .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1976, 73 (05) :1626-1630

[9]

MAMONT PS, UNPUBLISHED

[10]

MARTON LJ, 1975, CLIN CHEM, V21, P1721

← 1 2 →