FUNCTIONALITY OF NEWLY SYNTHESIZED DNA AS RELATED TO RNA SYNTHESIS DURING MITOTIC CYCLE IN PHYSARUM POLYCEPHALUM

被引：24

作者：

RAO, B

GONTCHAROFF, M

机构：

[1] Laboratoire de Biologie Cellulaire et Centre de Biologie et Biochimie du Développement, Faculté des Sciences

来源：

EXPERIMENTAL CELL RESEARCH | 1969年 / 56卷 / 2-3期

关键词：

D O I：

10.1016/0014-4827(69)90013-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The effect of FUDR on DNA and RNA synthesis was studied in the synchronous surface cultures of Physarum polycephalum. It was found that FUDR in conjunction with a proper concentration of uridine does not affect RNA synthesis during the G2 period. When the same concentration of FUDR and uridine was used during the S-period the synthesis of RNA was immediately reduced. These results suggest that at least part of the newly synthesized DNA becomes immediately functional in the synthesis of RNA. It was possible to differentiate in our system the direct and the indirect effect of FUDR on RNA synthesis. © 1969.

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页码：269 / +

页数：1

相关论文

共 27 条

[1] FORMATION AND FATE OF ABNORMAL RIBOSOMES OF E COLI CELLS TREATED WITH 5-FLUOROURACIL [J].

ANDOH, T ;

CHARGAFF, E .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1965, 54 (04) :1181-&

[2] EFFECT OF 5-FLUOROURACIL ON BACTERIAL PROTEIN AND RIBONUCLEIC ACID SYNTHESIS [J].

ARONSON, AI .

BIOCHIMICA ET BIOPHYSICA ACTA, 1961, 49 (01) :98-&

[3] STUDIES OF FLUORINATED PYRIMIDINES .18. DEGRADATION OF 5-FLUORO-2'-DEOXY-URIDINE AND RELATED COMPOUNDS BY NUCLEOSIDE PHOSPHORYLASE [J].

BIRNIE, GD ;

KROEGER, H ;

HEIDELBERGER, C .

BIOCHEMISTRY, 1963, 2 (03) :566-&

[4] SEQUENTIAL TEMPORAL REPLICATION OF DNA IN PHYSARUM POLYCEPHALUM [J].

BRAUN, R ;

MITTERMAYER, C ;

RUSCH, HP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1965, 53 (05) :924-+

[5] RIBONUCLEIC ACID SYNTHESIS IN VIVO IN SYNCHRONOUSLY DIVIDING PHYSARUM POLYCEPHALUM STUDIED BY CELL FRACTIONATION [J].

BRAUN, R ;

MITTERMAYER, C ;

RUSCH, HP .

BIOCHIMICA ET BIOPHYSICA ACTA, 1966, 114 (03) :527-+

[6] SEDIMENTATION PATTERNS OF PULSE-LABELED RNA IN MITOTIC CYCLE OF PHYSARUM POLYCEPHALUM [J].

BRAUN, R ;

MITTERMAYER, C ;

RUSCH, HP .

BIOCHIMICA ET BIOPHYSICA ACTA, 1966, 114 (01) :27-+

[7] DNA SYNTHESIS BY ISOLATED NUCLEI OF PHYSARUM POLYCEPHALUM [J].

BREWER, EN ;

RUSCH, HP .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1965, 21 (03) :235-&

[8] TRANSCRIPTION OF NUCLEAR DNA IN NUCLEI ISOLATED FROM PLASMODIA AT DIFFERENT STAGES OF CELL CYCLE OF PHYSARUM POLYCEPHALUM [J].

CUMMINS, JE ;

RUSCH, HP .

BIOCHIMICA ET BIOPHYSICA ACTA, 1967, 138 (01) :124-&

[9]

CUMMINS JE, 1966, J CELL BIOL, V31, pA24

[10] FLUCTUATION OF 32P DISTRIBUTION IN RAPIDLY LABELED RNA DURING CELL CYCLE OF PHYSARUM POLYCEPHALUM [J].

CUMMINS, JE ;

WEISFELD, GE ;

RUSCH, HP .

BIOCHIMICA ET BIOPHYSICA ACTA, 1966, 129 (02) :240-&