PGI2 ENHANCED CAMP CONTENT IN BOVINE CORONARY-ARTERIES IN THE PRESENCE OF ISOBUTYLMETHYLXANTHINE

被引：35

作者：

DEMBINSKAKIEC, A ^{[1
]}

RUCKER, W ^{[1
]}

SCHONHOFER, PS ^{[1
]}

机构：

[1] HANOVER UNIV MED, ZENTRUM PHARMACOL & TOXICOL, ABT 2, KARL WIECHERT ALLEE 9, D-3000 HANOVER 61, FED REP GER

来源：

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY | 1979年 / 308卷 / 02期

关键词：

Bovine coronary arteries; cAMP content; Endogenous PGI[!sub]2[!/sub] formation; PGI[!sub]2[!/sub;

D O I：

10.1007/BF00499051

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Incubation of bovine coronary artery (BCA) rings with isobutylmethylxanthine (IBMX) caused a time-dependent increase of c[cyclic]AMP content. This effect was blocked when the rings were preincubated with indomethacin or 15-hydroperoxy-arachidonic acid for 5 min; apparently the IBMX-induced increase in cAMP content may depend on endogenous PG[prostaglandin]I2 formation. PGE2 did not increase the cAMP content in BCA rings. Dipyridamole did not affect cAMP content, when used as a substitute for IBMX. Apparently PGI2 stimulates cAMP formation in arterial walls, but this effect only becomes visible in the presence of a phosphodiesterase inhibitor.

引用

页码：107 / 110

页数：4

共 20 条

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