RELATIONSHIP BETWEEN AFFINITY AND KINETICS IN A HAPTEN-ANTIBODY REACTION - STUDIES ON ANTI-CYCLIC AMP ANTIBODIES

被引：10

作者：

DENIZOT, FC

HIRN, MH

DELAAGE, MA

机构：

[1] Centre d'Immunologie, INSERM-CNRS de Marseille Luminy, 13288 Marseille Cédex 2

来源：

MOLECULAR IMMUNOLOGY | 1979年 / 16卷 / 07期

关键词：

D O I：

10.1016/0161-5890(79)90078-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The equilibrium and the kinetic properties of the binding of succinyl derivatives of cyclic AMP to anti-cyclic AMP antibodies have been investigated. High affinities (Kd in the range of 10-10-10-11 M) have been found to be associated with relatively low rate-constants for both association and dissociation. The results are discussed and compared with those previously obtained on other systems. © 1979.

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页码：509 / 513

页数：5

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