ENVIRONMENTAL-STRESS INCREASES EXTRACELLULAR DOPAMINE IN STRIATUM OF 6-HYDROXYDOPAMINE-TREATED RATS - INVIVO MICRODIALYSIS STUDIES

被引：54

作者：

KEEFE, KA

STRICKER, EM

ZIGMOND, MJ

ABERCROMBIE, ED

机构：

[1] UNIV PITTSBURGH, DEPT PSYCHIAT, PITTSBURGH, PA 15260 USA

[2] UNIV PITTSBURGH, CTR NEUROSCI, PITTSBURGH, PA 15260 USA

来源：

BRAIN RESEARCH | 1990年 / 527卷 / 02期

关键词：

6-Hydroxydopamine; Dopamine; Microdialysis; Neuroplasticity; Parkinson's disease; Stress; Striatum;

D O I：

10.1016/0006-8993(90)91158-D

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Bilateral intraventricular injections of 6-hydroxydopamine depleted dopamine (DA) in striatal tissue of rats by 88%. Tail shock increased DA in striatal extracellular fluid of these rats from 10 to 17 pg/20 μl as measured by microdialysis, values less than half those seen in normal striatum. The increase was observed even in rats that were akinetic. DA in extracellular fluid after stress was negatively correlated with behavioral performance. Thus, residual nigrostriatal DA neurons are responsive to stress but do not produce normal DA levels in striatal extracellular fluid. © 1990.

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页码：350 / 353

页数：4

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