MECHANISMS OF BLOOD-COAGULATION INDUCED BY LATEX-PARTICLES AND THE ROLES OF BLOOD-CELLS

被引：24

作者：

MIYAMOTO, M ^{[1
]}

SASAKAWA, S ^{[1
]}

OZAWA, T ^{[1
]}

KAWAGUCHI, H ^{[1
]}

OHTSUKA, Y ^{[1
]}

机构：

[1] KEIO UNIV,FAC SCI & TECHNOL,KOHOKU KU,YOKOHAMA,KANAGAWA 223,JAPAN

来源：

BIOMATERIALS | 1990年 / 11卷 / 06期

关键词：

Blood coagulation; hydrophobicity; latex particles; surface potential;

D O I：

10.1016/0142-9612(90)90091-4

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Latex particles with highly negative or positive charges shortened the clotting time of whole blood and platelet-rich plasma and activated platelet factor 3. Platelet-poor plasma was clotted by the particles with a highly negative charge, but not by those with a positive charge, except hydrophobic particles. Blood coagulation by positively-charged particles was attributed to platelet activation. An enhancement of blood coagulation was also observed in the presence of erythrocytes, leucocytes, their cell membranes or negatively charged phospholipids, and phosphatidylserine instead of platelets. Hydrophilic and lowcharged particles suppressed blood coagulation. © 1990.

引用

页码：385 / 388

页数：4

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