HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC ANALYSIS OF RIFAMPIN AND RELATED IMPURITIES IN PHARMACEUTICAL FORMULATIONS

被引：11

作者：

GRAHAM, KC

LEBELLE, MJ

WILSON, WL

机构：

[1] Drug Research Laboratories, Health Protection Branch, Health and Welfare Canada, Ottawa

来源：

JOURNAL OF LIQUID CHROMATOGRAPHY | 1979年 / 2卷 / 03期

关键词：

D O I：

10.1080/01483917908060069

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

High pressure liquid chromatography was employed for the assay of rifampin in capsules. A reverse phase RP-2 column and a mobile phase of 48% methanol, 5% tetrahydrofuran and 47% 0.05 M ammonium formate (pH 7.3) were used with detection at 254 nm. Rifampin was separated from all its major degradation products and quantitated. © 1979, Taylor & Francis Group, LLC. All rights reserved.

引用

页码：365 / 371

页数：7

共 7 条

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FEBVRE, N
METAYER, JP
SOUPPART, C
[J]. JOURNAL OF CHROMATOGRAPHY, 1978, 145 (02): : 319 - 324
[3] RIFAMPICIN - A NEW ORALLY ACTIVE RIFAMYCIN
MAGGI, N
PASQUALUCCI, CR
BALLOTTA, R
SENSI, P
[J]. CHEMOTHERAPY, 1966, 11 (05) : 285 - +
[4] SENSI P, 1966, ANTIMICROB AGENTS CH, P699
[5] ANALYSIS OF RIFAMPICIN AND OF ITS HYDROGENATED DERIVATIVES BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY
VLASAKOVA, V
BENES, J
ZIVNY, K
[J]. JOURNAL OF CHROMATOGRAPHY, 1978, 151 (02): : 199 - 205
[6] 1978, BRIT PHARMACOPOEIA
[7] 1977, CODE FEDERAL REGULAT

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