GAS CHROMATOGRAPHIC-MASS SPECTROMETRIC ASSAY FOR 9 HYDROXYPHENOLIC ACIDS IN UREMIC SERUM

被引：25

作者：

NIWA, T

OHKI, T

MAEDA, K

SAITO, A

OHTA, K

KOBAYASHI, K

机构：

[1] Department of Internal Medicine, Nagoya University Branch Hospital, Higashi-ku, Nagoya, 22-1, Higashisakura

来源：

CLINICA CHIMICA ACTA | 1979年 / 96卷 / 03期

关键词：

D O I：

10.1016/0009-8981(79)90435-2

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

A mass fragmentographic method for the determination of m-hydroxybenzoic acid, p-hydroxybenzoic acid, o-hydroxyphenylacetic acid, m-hydroxy-phenylacetic acid, p-hydroxyphenylacetic acid, vanillic acid, p-hydroxymandelic acid, homovanillic acid and vanilmandelic acid in uremie serum is described. The hydroxyphenolic acids were extracted from one ml of serum ultrafil trate. After trimethylsilylation, the extract was analyzed by a gas Chromatograph-mass spectrometer. Concentrations of nine hydroxyphenolic acids are higher in uremie serum. In particular, p-hydroxybenzoic acid and p-hydroxyphenylacetic acid are markedly increased in uremic serum. The influence of hemodialysis on the hydroxyphenolic acids was studied by quantitating the acids before and after hemodialysis. © 1979.

引用

页码：247 / 254

页数：8

共 19 条

[1]

Bajaj V R, 1973, Indian J Med Sci, V27, P235

[2] STUDY OF INTESTINAL TYROSINE METABOLISM USING STABLE ISOTOPES AND GAS CHROMATOGRAPHY MASS SPECTROMETRY [J].