CHARACTERIZATION OF AN INHIBITORY MONOCLONAL ANTIBODY-DEFINED EPITOPE ON A MALARIA VACCINE CANDIDATE ANTIGEN

被引：29

作者：

RAMASAMY, R ^{[1
]}

JONES, G ^{[1
]}

LORD, R ^{[1
]}

机构：

[1] QUEENSLAND INST MED RES,BRISBANE,AUSTRALIA

来源：

IMMUNOLOGY LETTERS | 1990年 / 23卷 / 04期

关键词：

Epitope; Malaria; Merozoite surface; Monoclonal antibody; Plasmodium falciparum;

D O I：

10.1016/0165-2478(90)90077-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A monoclonal antibody that recognises a recently characterised 45-kDa merozoite surface antigen of the human malaria parasite Plasmodium falciparum inhibits the growth of the asexual blood stages of the parasite in vitro. The corresponding epitope has been determined by testing the reactivity of the antibody with sequentially overlapping octapeptides. A synthetic peptide containing the epitope elicits antibodies that react with the native antigen. Epitope mapping in this manner is useful in the design of synthetic vaccines against malaria. © 1990.

引用

页码：305 / 310

页数：6

共 12 条

[11] MEROZOITE SURFACE-COAT PRECURSOR PROTEIN COMPLETELY PROTECTS AOTUS MONKEYS AGAINST PLASMODIUM-FALCIPARUM MALARIA [J].