PHARMACOLOGICAL STUDY ON CITRUS-FRUITS .2. ANTIALLERGIC EFFECT OF FRUIT OF CITRUS-UNSHIU MARKOVICH .2. ON FLAVONOID COMPONENTS

被引：33

作者：

MATSUDA, H ^{[1
]}

YANO, M ^{[1
]}

KUBO, M ^{[1
]}

IINUMA, M ^{[1
]}

OYAMA, M ^{[1
]}

MIZUNO, M ^{[1
]}

机构：

[1] GIFU COLL PHARM, DEPT PHARMACOGNOSY, GIFU 502, JAPAN

来源：

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN | 1991年 / 111卷 / 03期

关键词：

CITRUS-UNSHIU; FRUIT; FLAVONOID; HESPERIDIN; ANTIALLERGIC ACTION; MAST CELL; 48-HOUR HOMOLOGOUS PASSIVE CUTANEOUS ANAPHYLAXIS;

D O I：

10.1248/yakushi1947.111.3_193

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A study was carried out to clarify the active component of green fruit of Citrus unshiu MAKOVICH on the type I allergic reaction. The flavonoid component, isolated from its methanolic extract, hesperidin, was found to inhibit histamine release from peritoneal mast cells of rats induced by compound 48/80. Forty eight-hour homologous passive cutaneous anaphylaxis (PCA) in intact rats was significantly inhibited by the oral administration of hesperidin. However, the anti-allergic action on PCA was not observed in adrenalectomized rats. These results suggests that hesperidin is an effective component of the fruit of Citrus unshiu with the anti-allergic action against the type I reaction.

引用

页码：193 / 198

页数：6

共 8 条

[1]

CHUN Y-T, 1989, Shoyakugaku Zasshi, V43, P314

[2]

IINUMA M, 1980, CHEM PHARM BULL, V28, P717

[3]

ISHIZAKA K, 1970, CLIN EXP IMMUNOL, V6, P25

[4]

Johansson S G, 1972, Prog Clin Immunol, V1, P157

[5]

MIZUNO M, 1987, CHEM PHARM BULL, V35, P3025

[6]

SHORE PA, 1959, J PHARMACOL EXP THER, V127, P182

[7] ACTIVE BRONCHIAL ANAPHYLAXIS IN RAT [J].

STOTLAND, LM ;

SHARE, NN .

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 1974, 52 (06) :1114-1118

[8] ISOLATION OF BIOLOGICALLY INTACT MAST CELLS [J].

UVNAS, B ;

THON, IL .

EXPERIMENTAL CELL RESEARCH, 1959, 18 (03) :512-520

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