ULTRA-PURE POLYMERIZED BOVINE HEMOGLOBIN BLOOD SUBSTITUTE - EFFECTS ON THE CORONARY CIRCULATION

被引：15

作者：

HODAKOWSKI, GT ^{[1
]}

PAGE, RD ^{[1
]}

HARRINGER, W ^{[1
]}

JACOBS, EE ^{[1
]}

LARAIA, PJ ^{[1
]}

SVIZZERO, T ^{[1
]}

GUERRERO, JL ^{[1
]}

AUSTEN, WG ^{[1
]}

VLAHAKES, GJ ^{[1
]}

机构：

[1] HARVARD UNIV,SCH MED,BOSTON,MA 02115

来源：

BIOMATERIALS ARTIFICIAL CELLS AND IMMOBILIZATION BIOTECHNOLOGY | 1992年 / 20卷 / 2-4期

关键词：

D O I：

10.3109/10731199209119699

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The effects of stroma-free hemoglobin (SFHgb) on the coronary circulation remain unclear. An intact canine model utilizing intracoronary adenosine to abolish the confounding effect of autoregulation was used to study maximal myocardial oxygen delivery during progressive hemodilution with polymerized bovine SFHgb. The circumflex coronary artery was instrumented with a flow probe, hydraulic constrictor, and proximal and distal catheters for adenosine infusion and distal pressure measurement, respectively. This preparation was used to generate diastolic coronary pressure-flow relations during maximal vasodilation. Maximal coronary conductance and maximal myocardial oxygen delivery were determined in two groups of 7 dogs each following hemodilution, first with 6% hetastarch (Control), followed by further hemodilution with ultra-pure, polymerized, bovine SFHgb. After hemodilution with SFHgb, maximal coronary flow increased slightly without evidence of coronary vasoconstriction. Since hemodilution with this material increases oxygen carrying capacity, maximal oxygen delivery is greater than Control, despite the very low canine hematocrit. These findings suggest: 1) SFHgb can provide adequate oxygen delivery to the myocardium despite extreme degrees of hemodilution, and 2) in this intact model, there is no evidence of adverse coronary vasomotion.

引用

页码：669 / 672

页数：4

共 6 条

[1] MINIATURE HYDRAULIC OCCLUDER FOR ZERO BLOOD FLOW DETERMINATION [J].