VIRUS-SPECIFIC CYTOTOXIC LYMPHOCYTE-RESPONSE IN A NEUROTROPIC MURINE LEUKEMIA-VIRUS INFECTION

被引：13

作者：

ROBBINS, DS

HOFFMAN, PM

机构：

[1] DEPT VET AFFAIRS MED CTR,RETROVIRUS RES CTR 151,3900 LOCH RAVEN BLVD,BALTIMORE,MD 21218

[2] UNIV MARYLAND,DEPT PATHOL,BALTIMORE,MD 21201

[3] UNIV MARYLAND,DEPT NEUROL,BALTIMORE,MD 21201

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1991年 / 31卷 / 01期

关键词：

MURINE LEUKEMIA VIRUS; NEURODEGENERATIVE DISEASE; CYTOTOXIC LYMPHOCYTE-T;

D O I：

10.1016/0165-5728(91)90081-H

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

NFS/N mice infected with neurotropic Cas-Br-M murine leukemia virus (MuLV) at 21 days of age were resistant to neurologic disease and demonstrated MuLV-specific cytotoxic T lymphocyte (CTL) activity in spleen cells after in vitro stimulation. NFS/N mice infected with Cas-Br-M MuLV at 2 days of age failed to generate a significant MuLV-specific CTL response and developed neurologic disease 5-8 weeks later. Protection from neurologic disease transferred with fewer in vitro stimulated immune spleen cells than immune T cells from NFS/N mice infected with Cas-Br-M MuLV at 21 days of age. Cas-Br-M MuLV-specific CTL may play an important role in resistance to the paralytic effects of Cas-Br-M MuLV infection by affecting virus dissemination to the central nervous system.

引用

页码：9 / 17

页数：9

共 18 条

[1] EVIDENCE FOR AN H-2-VIRAL PROTEIN COMPLEX ON CELL-SURFACE AS BASIS FOR H-2 RESTRICTION OF CYTOTOXICITY [J].