PRIMAQUINE-INDUCED SUPEROXIDE PRODUCTION BY BETA-THALASSEMIC RED-BLOOD-CELLS

被引：18

作者：

GRINBERG, LN ^{[1
]}

SHALEV, O ^{[1
]}

GOLDFARB, A ^{[1
]}

RACHMILEWITZ, EA ^{[1
]}

机构：

[1] HEBREW UNIV JERUSALEM, DEPT MED, JERUSALEM, ISRAEL

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1992年 / 1139卷 / 03期

关键词：

SUPEROXIDE; RED BLOOD CELL; THALASSEMIA; PRIMAQUINE; OXIDATIVE STRESS;

D O I：

10.1016/0925-4439(92)90141-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Primaquine, a prooxidant antimalarial drug, incubated with human red blood cells (RBC) induced marked superoxide generation in the cells as detected by exogenous cytochrome c reduction. In the presence of primaquine, beta-thalassemic RBC produced significantly more superoxide than normal RBC, thus reflecting the vulnerability of beta-thalassemic cells to oxidative stress.

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页码：248 / 250

页数：3

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