INVITRO EFFECT OF INTERLEUKIN-1-BETA ON HUMAN GLIOMA CELL-LINES - REGULATION OF CELL-PROLIFERATION AND IL-6 PRODUCTION

被引：16

作者：

CINQUE, S

WILLEMS, J

DEPRAETERE, S

VERMEIRE, L

JONIAU, M

机构：

[1] KATHOLIEKE UNIV LEUVEN,LAB BIOCHEM IRC,CAMPUS KORTRIJK,B-8500 KORTRIJK,BELGIUM

[2] KATHOLIEKE UNIV LEUVEN,DIV STAT,B-8500 KORTRIJK,BELGIUM

来源：

IMMUNOLOGY LETTERS | 1992年 / 34卷 / 03期

关键词：

GLIOMA; INTERLEUKIN-1; INTERLEUKIN-6; CYCLIC AMP PATHWAY;

D O I：

10.1016/0165-2478(92)90223-B

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The human glioma cell lines U251 and HP591 were chosen as ''in vitro'' models for functional astrocytes. When cultured in the presence of IL-1beta these cell lines demonstrated a marked increase in interleukin-6 production and in [H-3]-thymidine uptake. The addition of dbcAMP could mimick the first effect of IL-1beta but at the same time suppressed cell proliferation. These results suggest that IL-1beta possibly exerts one of its biological effects (IL-6 synthesis) by means of the cyclic AMP pathway.

引用

页码：267 / 271

页数：5

共 10 条

[1] STIMULATION OF CRP SECRETION IN HEPG2 CELLS - COOPERATIVE EFFECT OF DEXAMETHASONE AND INTERLEUKIN-6 [J].