INVOLVEMENT OF NITRIC-OXIDE IN BASAL AND INTERLEUKIN-1-BETA-INDUCED CRH AND ACTH RELEASE IN-VITRO

被引：44

作者：

BRUNETTI, L

PREZIOSI, P

RAGAZZONI, E

VACCA, M

机构：

[1] UNIV CATTOLICA SACRO CUORE, DEPT PHARMACOL, I-00168 ROME, ITALY

[2] UNIV G DANNUNZIO, DEPT PHARMACOL, I-66100 CHIETI, ITALY

来源：

LIFE SCIENCES | 1993年 / 53卷 / 13期

关键词：

D O I：

10.1016/0024-3205(93)90267-7

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

N(G)-Nitro-L-arginine, an inhibitor of nitric oxide synthase, does not influence CRH basal release but is able to modify ACTH basal secretion and to block interleukin-1beta-induced CRH and ACTH release from rat hypothalamic and anterior pituitary cell cultures in vitro. The data suggest a different involvement of NO at hypothalamic and pituitary level.

引用

页码：PL219 / PL222

页数：4

共 11 条

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