TOTAL SYNTHESIS OF CYCLOTHEONAMIDE-B, A FACILE ROUTE TOWARDS ANALOGS

被引：13

作者：

BASTIAANS, HMM

VANDERBAAN, JL

OTTENHEIJM, HCJ

机构：

[1] LEIDEN AMSTERDAM CTR DRUG RES,DEPT PHARMACOCHEM,DIV MED CHEM,1081 HV AMSTERDAM,NETHERLANDS

[2] VRIJE UNIV AMSTERDAM,SCHEIKUNDIG LAB,1081 HV AMSTERDAM,NETHERLANDS

[3] NV ORGANON,SCI DEV GRP,5340 BH OSS,NETHERLANDS

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 33期

关键词：

D O I：

10.1016/0040-4039(95)01153-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A flexible, convergent synthesis of Cyclotheonamide B (1b) was developed, starting from the constituent amino acids, using conventional benzyl-, t-butyl- and allyl-based protecting groups. By modification of the key intermediates, this approach allows the preparation of cyclotheonamide analogues.

引用

页码：5963 / 5966

页数：4

共 15 条

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