ERYTHROMYCIN-VI - KINETICS OF ACID-CATALYZED HYDROLYSIS OF ERYTHROMYCIN OXIME AND ERYTHROMYCYLAMINE

被引：15

作者：

LAZAREVSKI, T

RADOBOLJA, G

DJOKIC, S

机构：

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1978年 / 67卷 / 07期

关键词：

Antibacterials—erythromycin oxime and amine; kinetics of acid‐catalyzed hydrolysis; Erythromycin oxime and amine—kinetics of acid‐catalyzed hydrolysis; Hydrolysis; acid catalyzed—erythromycin oxime and amine; kinetics; Kinetics—acid‐catalyzed hydrolysis of erythromycin oxime and amine;

D O I：

10.1002/jps.2600670747

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Kinetic data were obtained, by qualitative and quantitative analysis, of the hydrolytic degradation of erythromycin oxime and erythromycylamine separated by TLC. The pseudo‐first‐order rate constants were determined at three temperatures (17, 26, and 36°), and the temperature dependency of the reaction was studied. The activation energy for the hydrolysis and methanolysis of the compounds was calculated. The factors contributing to the differences in the reaction rate are discussed. Copyright © 1978 Wiley‐Liss, Inc., A Wiley Company

引用

页码：1031 / 1033

页数：3

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