SEQUENCE OF I-E GENES FROM AUTOIMMUNE NEW-ZEALAND WHITE MICE

被引：9

作者：

SMITH, LR ^{[1
]}

THEOFILOPOULOS, AN ^{[1
]}

机构：

[1] SCRIPPS CLIN & RES FDN, DEPT IMMUNOL, IMM3, 1066 N TORREY PINES RD, LA JOLLA, CA 92037 USA

来源：

ARTHRITIS AND RHEUMATISM | 1990年 / 33卷 / 04期

关键词：

D O I：

10.1002/art.1780330418

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Autoimmune New Zealand white (NZW) mice contribute to (New Zealand black × New Zealand white)F1 mice 1 or more major histocompatibility complex‐linked genes that strongly correlate with susceptibility to murine lupus. The NZW class II major histocompatibility complex genes, I‐Eα and I‐Eβ, were cloned and sequenced and found to differ from normal B10.PL (H‐2u) mice by 3 amino acids in the first domain of the I‐Eβ subunit. Of these differences, the arginine at position 72 of NZW mice could be an important disease determinant since it lies in a predicted antigen‐binding cleft. Copyright © 1990 American College of Rheumatology

引用

页码：583 / 586

页数：4

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