SEQUENCE OF I-E GENES FROM AUTOIMMUNE NEW-ZEALAND WHITE MICE

被引:9
作者
SMITH, LR [1 ]
THEOFILOPOULOS, AN [1 ]
机构
[1] SCRIPPS CLIN & RES FDN, DEPT IMMUNOL, IMM3, 1066 N TORREY PINES RD, LA JOLLA, CA 92037 USA
来源
ARTHRITIS AND RHEUMATISM | 1990年 / 33卷 / 04期
关键词
D O I
10.1002/art.1780330418
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Autoimmune New Zealand white (NZW) mice contribute to (New Zealand black × New Zealand white)F1 mice 1 or more major histocompatibility complex‐linked genes that strongly correlate with susceptibility to murine lupus. The NZW class II major histocompatibility complex genes, I‐Eα and I‐Eβ, were cloned and sequenced and found to differ from normal B10.PL (H‐2u) mice by 3 amino acids in the first domain of the I‐Eβ subunit. Of these differences, the arginine at position 72 of NZW mice could be an important disease determinant since it lies in a predicted antigen‐binding cleft. Copyright © 1990 American College of Rheumatology
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页码:583 / 586
页数:4
相关论文
共 20 条
[1]   THE 1ST EXTERNAL DOMAIN OF THE NONOBESE DIABETIC MOUSE CLASS-II I-A BETA-CHAIN IS UNIQUE [J].
ACHAORBEA, H ;
MCDEVITT, HO .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (08) :2435-2439
[2]  
AYANE M, 1986, J IMMUNOL, V137, P948
[3]  
BENOIST CO, 1987, CELL, V34, P167
[4]   STRUCTURE OF THE HUMAN CLASS-I HISTOCOMPATIBILITY ANTIGEN, HLA-A2 [J].
BJORKMAN, PJ ;
SAPER, MA ;
SAMRAOUI, B ;
BENNETT, WS ;
STROMINGER, JL ;
WILEY, DC .
NATURE, 1987, 329 (6139) :506-512
[5]   A HYPOTHETICAL MODEL OF THE FOREIGN ANTIGEN-BINDING SITE OF CLASS-II HISTOCOMPATIBILITY MOLECULES [J].
BROWN, JH ;
JARDETZKY, T ;
SAPER, MA ;
SAMRAOUI, B ;
BJORKMAN, PJ ;
WILEY, DC .
NATURE, 1988, 332 (6167) :845-850
[6]  
CHOMCZYNSKI P, 1987, ANAL BIOCHEM, V162, P156, DOI 10.1016/0003-2697(87)90021-2
[7]   SEQUENCE-ANALYSIS AND STRUCTURE-FUNCTION CORRELATIONS OF MURINE-Q, MARINE-K, MARINE-U, MARINE-S, AND MARINE-F HAPLOTYPE I-A-BETA CDNA CLONES [J].
ESTESS, P ;
BEGOVICH, AB ;
KOO, M ;
JONES, PP ;
MCDEVITT, HO .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (11) :3594-3598
[8]   H-2 HAPLOTYPES OF STRAINS DBR7, B10.NZW, NFS, BQ2, STU, TO1, AND TO2 [J].
FIGUEROA, F ;
TEWARSON, S ;
NEUFELD, E ;
KLEIN, J .
IMMUNOGENETICS, 1982, 15 (04) :431-436
[9]   T-CELL-RECEPTOR BETA-CHAIN AND I-A-BETA-CHAIN GENES OF NORMAL SWR MICE ARE LINKED WITH THE DEVELOPMENT OF LUPUS NEPHRITIS IN NZB X SWR CROSSES [J].
GHATAK, S ;
SAINIS, K ;
OWEN, FL ;
DATTA, SK .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (19) :6850-6853
[10]   ENHANCING EFFECT OF H-2-LINKED NZW GENE(S) ON THE AUTOIMMUNE TRAITS OF (NZB X NZW)F1 MICE [J].
HIROSE, S ;
NAGASAWA, R ;
SEKIKAWA, I ;
HAMAOKI, M ;
ISHIDA, Y ;
SATO, H ;
SHIRAI, T .
JOURNAL OF EXPERIMENTAL MEDICINE, 1983, 158 (01) :228-233