REACTIVATION OF PRECORE MUTANT HEPATITIS-B VIRUS LEADING TO FULMINANT HEPATIC-FAILURE FOLLOWING CYTOTOXIC TREATMENT

被引：80

作者：

YOSHIBA, M ^{[1
]}

SEKIYAMA, K ^{[1
]}

SUGATA, F ^{[1
]}

OKAMOTO, H ^{[1
]}

YAMAMOTO, K ^{[1
]}

YOTSUMOTO, S ^{[1
]}

机构：

[1] JICHI MED SCH, DIV IMMUNOL, MINAMI KAWACHI, TOCHIGI 32904, JAPAN

来源：

DIGESTIVE DISEASES AND SCIENCES | 1992年 / 37卷 / 08期

关键词：

HEPATITIS-B VIRUS; MUTATION; REACTIVATION;

D O I：

10.1007/BF01296569

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Three hepatitis B virus carriers who were HB(e)Ag negative and having normal liver function developed fulminant hepatitis with evidence of HBV replication following intensive chemotherapy for non-Hodgkin's lymphoma. Each was continuously negative for HB(e)Ag. Analysis of the precore region of HBV isolated from each demonstrated that the HBV of each had a point mutation in the precore region that inhibited the synthesis and the release of hepatitis B(e) antigen. This observation suggests that all HB carriers receiving either immunosuppressive or cytotoxic therapy should be monitored closely even if standard assays suggest that viral replication is not present. Sudden enhanced replication of a HBV mutant as a result of such therapy can be a cause of either very severe hepatitis or occasionally fulminant hepatitis.

引用

页码：1253 / 1259

页数：7

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