A H-1-NMR METHOD FOR THE DETERMINATION OF ENANTIOMERIC EXCESS AND ABSOLUTE-CONFIGURATION OF CIS-DIHYDRODIOL METABOLITES OF POLYCYCLIC ARENES AND HETEROARENES

被引：31

作者：

BOYD, DR ^{[1
]}

SHARMA, ND ^{[1
]}

BOYLE, R ^{[1
]}

MCMORDIE, RAS ^{[1
]}

CHIMA, J ^{[1
]}

DALTON, H ^{[1
]}

机构：

[1] UNIV WARWICK,DEPT BIOL SCI,COVENTRY CV4 7AL,W MIDLANDS,ENGLAND

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 09期

关键词：

BACTERIAL OXIDATION; PSEUDOMONAS-PUTIDA UV4; CIS-DIHYDRODIOL STEREOCHEMISTRY; BENZOFURAN;

D O I：

10.1016/S0040-4039(00)91907-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Metabolism of benzofuran and 2,3-dihydrobenzofuran by P.putida UV4 each yielded cis-dihydrodiols; catalytic hydrogenation of the cis-dihydrodiols obtained from polycyclic arenes and azaarenes followed by diMTPA ester formation (using both R- and S-MTPA) on the cis-tetrahydrodiols formed the basis of a H-1-NMR method for the determination of both enantiomeric excess and absolute configuration.

引用

页码：1241 / 1244

页数：4

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