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MITOGEN-ACTIVATED PROTEIN-KINASES - VERSATILE TRANSDUCERS FOR CELL SIGNALING

被引：442
作者：
PELECH, SL
SANGHERA, JS
机构：
[1] UNIV BRITISH COLUMBIA, BIOMED RES LAB, VANCOUVER V6T 1W5, BC, CANADA
[2] UNIV BRITISH COLUMBIA, DEPT MED, VANCOUVER V6T 1W5, BC, CANADA
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 1992年 / 17卷 / 06期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1016/S0968-0004(00)80005-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Mitogen-activated protein (MAP) kinases are proline-directed serine/threonine protein kinases that are activated via phosphorylation of their own tyrosine residues. Highly conserved during eukaryotic evolution, they serve as common signaling components in distinct transduction pathways initiated by many stimuli. They have been implicated in the control of a broad spectrum of cellular events but are particularly known for their possible roles in cell cycle progression and the control of meiosis.
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收藏
页码：233 / 238
页数：6
相关论文
共 46 条
[1]  
AHN NG, 1991, J BIOL CHEM, V266, P4220
[2]   TYROSINE PHOSPHORYLATION OF A YEAST 40 KDA PROTEIN OCCURS IN RESPONSE TO MATING PHEROMONE [J].
BALLARD, MJ ;
TYNDALL, WA ;
SHINGLE, JM ;
HALL, DJ ;
WINTER, E .
EMBO JOURNAL, 1991, 10 (12) :3753-3758
[3]  
BLENIS J, 1991, CANCER CELL-MON REV, V3, P445
[4]   IDENTIFICATION OF MULTIPLE EXTRACELLULAR SIGNAL-REGULATED KINASES (ERKS) WITH ANTIPEPTIDE ANTIBODIES [J].
BOULTON, TG ;
COBB, MH .
CELL REGULATION, 1991, 2 (05) :357-371
[5]   ERKS - A FAMILY OF PROTEIN-SERINE THREONINE KINASES THAT ARE ACTIVATED AND TYROSINE PHOSPHORYLATED IN RESPONSE TO INSULIN AND NGF [J].
BOULTON, TG ;
NYE, SH ;
ROBBINS, DJ ;
IP, NY ;
RADZIEJEWSKA, E ;
MORGENBESSER, SD ;
DEPINHO, RA ;
PANAYOTATOS, N ;
COBB, MH ;
YANCOPOULOS, GD .
CELL, 1991, 65 (04) :663-675
[6]   NUCLEAR-LOCALIZATION AND REGULATION OF ERK-ENCODED AND RSK-ENCODED PROTEIN-KINASES [J].
CHEN, RH ;
SARNECKI, C ;
BLENIS, J .
MOLECULAR AND CELLULAR BIOLOGY, 1992, 12 (03) :915-927
[7]  
CHENG HC, 1991, J BIOL CHEM, V266, P17919
[8]  
CLARKLEWIS I, 1991, J BIOL CHEM, V266, P15180
[9]   EXTRACELLULAR SIGNAL-REGULATED KINASES - ERKS IN PROGRESS [J].
COBB, MH ;
BOULTON, TG ;
ROBBINS, DJ .
CELL REGULATION, 1991, 2 (12) :965-978
[10]   A PUTATIVE PROTEIN-KINASE OVERCOMES PHEROMONE-INDUCED ARREST OF CELL CYCLING IN S-CEREVISIAE [J].
COURCHESNE, WE ;
KUNISAWA, R ;
THORNER, J .
CELL, 1989, 58 (06) :1107-1119
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