BEHAVIORAL AND CARDIAC RESPONSES AFTER INTRACEREBROVENTRICULAR CORTICOTROPIN-RELEASING HORMONE (CRH) ADMINISTRATION - ROLE OF ADRENAL-CORTICAL HORMONES

被引:20
作者
KORTE, SM
EISINGA, W
TIMMERMAN, W
NYAKAS, C
BOHUS, B
机构
[1] Department of Animal Physiology, University of Groningen, 9750 AA Haren
关键词
D O I
10.1016/0018-506X(92)90007-I
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Intracerebroventricularly (icv) administered corticotropin-releasing hormone (CRH) produces a dose-dependent increase in heart rate in association with behavioral activation. The present study was designed to investigate whether these CRH-induced responses are dependent on adrenal function. The effects of adrenalectomy (ADX) and subsequent corticosterone replacement were studied. Administration icv of 300 ng of CRH failed to produce behavioral activation and tachycardia in ADX rats. Corticosterone replacement restored the CRH-induced behavioral response to preoperative levels, whereas the CRH-induced tachycardia was partially restored. This latter result may be related to the fact that the baseline heart rate of ADX animals appeared to be significantly higher than that of corticosterone-treated ADX animals. It is concluded that circulating adrenal corticosterone in ADX rats is involved in the expression of the behavioral and cardiac effect of central CRH. © 1992.
引用
收藏
页码:375 / 384
页数:10
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