RECENT ADVANCES IN PHARMACEUTICAL ANALYSIS WITH POTENTIOMETRIC MEMBRANE SENSORS

被引:151
作者
COSOFRET, VV
BUCK, RP
机构
[1] Department of Chemistry, University of North Carolina, Chapel Hill, NC
[2] Department of Chemistry, University of Michigan, Ann Arbor, MI
关键词
ION-SELECTIVE ELECTRODES; MEMBRANE SENSORS; DRUGS; PHARMACEUTICAL ANALYSIS; DISSOLUTION; PHARMACOKINETICS;
D O I
10.1080/10408349308048818
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
The development and applications of ion-selective membrane electrodes continue to provide excitement is expanding areas of analytical chemistry, including analytical pharmaceutical research and analysis, because these sensors offer the advantages of simple design, construction, and manipulation, reasonable selectivity, fast response time, applicability to colored and turbid solutions, and possible interfacing with automated and computerized systems. The combination of membrane sensors with flow injection analysis (FIA) for the determination of various organic ions of biological interest (e.g., drugs) is a new promising area with many applications. This review covers the material that is of interest to those who deal with ion-selective electrodes in organic and pharmaceutical analysis.
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页码:1 / 58
页数:58
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