CHIRAL REQUIREMENTS FOR TUMOR PROMOTERS - CONFORMATIONS AND ACTIVITY OF BENZOLACTAMS

被引：14

作者：

ENDO, Y

OHNO, M

HIRANO, M

TAKEDA, M

ITAI, A

SHUDO, K

机构：

[1] Faculty of Pharmaceutical Sciences, University of Tokyo, Bunkyo-ku, Tokyo, 113

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 03期

关键词：

D O I：

10.1016/0960-894X(94)80023-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

(-)-Benzolactam-V8-310 ((-)-1), which reproduces the twist conformation and biological activity of teleocidins, its antipode ((+)-1), and the epi-benzolactams ((-)-2 and (+)-2) were synthesized as optically pure forms. Structure-activity results indicate that the stereochemistry at C-5 plays a critical role in the binding to the receptor(s).

引用

页码：491 / 494

页数：4

共 13 条

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