A PRACTICAL SYNTHETIC ROUTE TO ENANTIOPURE 3-ARYLOXY-1,2-PROPANEDIOLS FROM CHIRAL GLYCIDOL

被引：45

作者：

CHEN, JA ^{[1
]}

SHUM, W ^{[1
]}

机构：

[1] ARCO CHEM CO,NEWTOWN SQ,PA 19073

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 14期

关键词：

D O I：

10.1016/0040-4039(95)00282-H

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

Chiral 3-aryloxy-1,2-propanediols of >98% ee can be obtained in high yield by the nucleophilic addition of substituted phenols to chiral glycidol in the presence of triethylamine catalyst followed by recrystallization in absolute ethanol. Several enantiopure compounds of pharmaceutical significance are presented as examples.

引用

页码：2379 / 2380

页数：2

共 7 条

[1]

[Anonymous], 1983, US Pat., Patent No. [4 390 732, 4390732]

[2]

2 ENANTIOSELECTIVE SYNTHESES OF THE DIOL PRECURSOR OF THE BIOLOGICALLY MOST ACTIVE ISOMER OF AN INSECT GROWTH-REGULATOR [J].