ROLE OF 5-HYDROXYTRYPTAMINE IN DRUG-INDUCED ANTINOCICEPTION

被引：41

作者：

SUGRUE, MF ^{[1
]}

机构：

[1] ORGANON LABS LTD,ORGANON SCI DEV GRP,DEPT PHARMACOL,NEWHOUSE ML1 5SH,ENGLAND

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 1979年 / 65卷 / 04期

关键词：

D O I：

10.1111/j.1476-5381.1979.tb07881.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of four specific inhibitors of 5‐hydroxytryptamine (5‐HT) uptake on morphine‐, methadone‐ or pethidine‐induced antinociception was studied in rats. Antinociception was assessed by means of hot plate (55°C) reaction times. The effect of the compounds on the uptake of [3H]‐5‐HT into rat whole brain synaptosomes was also investigated. Pretreatment with Org 6582, citalopram, zimelidine or femoxetine at doses devoid of antinociceptive activity potentiated morphine‐ but not methadone‐ or pethidine‐induced antinociception. A temporal correlation existed between the ability of Org 6582 to potentiate morphine‐induced antinociception and to block synaptosomal [3H]‐5‐HT uptake. 5‐HT plays a critical role in the antinociceptive effect of morphine but not of methadone or pethidine. 1979 British Pharmacological Society

引用

页码：677 / 681

页数：5

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