AGING OF CHICK-EMBRYO FIBROBLASTS INVITRO .3. POLYPLOID CELL ACCUMULATION

被引：27

作者：

KAJI, K

MATSUO, M

机构：

[1] Tokyo Metropolitan Institute of Gerontology, Itabashiku, Tokyo, 173

来源：

EXPERIMENTAL CELL RESEARCH | 1979年 / 119卷 / 02期

关键词：

D O I：

10.1016/0014-4827(79)90351-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The accumulation of polyploid cells during the lifespan of chick embryo fibroblasts was examined. The nuclear area of each stained nucleus in the chick cells is virtually proportional to its relative DNA content. Changes in mean nuclear area of the cells with advancing aging were observed. The mean nuclear area increases at the latest culture stage when growth rate notably declines, and their increase follows an increase in multinuclear cells. In the senescent cells, there are the ploidy classes of 2C, 4C, 8C, 16C, 32C and 64C, being defined as 2nC. The mechanism of age-dependent polyploidization is also discussed. © 1979.

引用

页码：231 / 236

页数：6

共 27 条

[1] THE NUCLEOPROTEIN CONTENT OF FIBROBLASTS GROWING INVITRO .4. CHANGES IN THE RIBONUCLEIC ACID PHOSPHORUS (RNAP) AND DEOXYRIBONUCLEIC ACID PHOSPHORUS (DNAP) CONTENT [J].