A HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC METHOD FOR THE DETERMINATION OF STOBADIN PHARMACOKINETICS IN SERUM

被引：19

作者：

SOLTES, L ^{[1
]}

KALLAY, Z ^{[1
]}

BEZEK, S ^{[1
]}

FEDELESOVA, V ^{[1
]}

机构：

[1] INST NATL HLTH, PHARMACOTHERAPY CLIN, CS-83308 BRATISLAVA, CZECHOSLOVAKIA

来源：

BIOPHARMACEUTICS & DRUG DISPOSITION | 1991年 / 12卷 / 01期

关键词：

PHARMACOKINETICS; BIOAVAILABILITY; STOBADIN; GAMMA-CARBOLINE; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY;

D O I：

10.1002/bdd.2510120104

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A high-performance liquid chromatographic method was developed to determine stobadin pharmacokinetics in dog and man. The relative bioavailability of stobadin dipalmitate compared with dihydrochloride was 46.4 per cent in dog. In man peak serum concentrations ranged from 12 to 289 ng ml(-1) after a single oral dose of stobadin dipalmitate (0.79 to 2.5 mg kg(-1).

引用

页码：29 / 35

页数：7

共 14 条

[1]

BENES L, 1989, Drugs of the Future, V14, P135

[2]

BITTEREROVA J, 1990, PHARMAZIE, V45, P437

[3]

BITTEREROVA J, 1988, CS FYSIOL, V37, P241

[4]

Gibaldi M., 1982, PHARMACOKINETICS, Vsecond

[5] GAS-CHROMATOGRAPHIC DETERMINATION OF PENTACAINE IN RAT SERUM [J].

MARKO, V ;

STEFEK, M ;

SOLTES, L .

JOURNAL OF CHROMATOGRAPHY, 1985, 339 (02) :410-413

[6] DETERMINATION OF STOBADINE, A NOVEL CARDIOPROTECTIVE DRUG, USING CAPILLARY GAS-CHROMATOGRAPHY WITH NITROGEN PHOSPHORUS DETECTION AFTER ITS SELECTIVE SOLID-PHASE EXTRACTION FROM SERUM [J].

MARKO, V .

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1988, 433 :269-275

[7]

MARKO V, 1985, PHARMAZIE, V40, P192

[8] EXTENDED LEAST-SQUARES NONLINEAR-REGRESSION - A POSSIBLE SOLUTION TO THE CHOICE OF WEIGHTS PROBLEM IN ANALYSIS OF INDIVIDUAL PHARMACOKINETIC DATA [J].

PECK, CC ;

BEAL, SL ;

SHEINER, LB ;

NICHOLS, AI .

JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS, 1984, 12 (05) :545-558

[9] CURVE FITTING AND MODELING IN PHARMACOKINETICS AND SOME PRACTICAL EXPERIENCES WITH NONLIN AND A NEW PROGRAM FUNFIT [J].

PEDERSEN, PV .

JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS, 1977, 5 (05) :513-531

[10] SOLVENT-EXTRACTION AND RADIOMETRIC DETERMINATION OF H-3 STOBADINE IN BIOLOGICAL-MATERIAL [J].

SCASNAR, V ;

STEFEK, M .

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY-ARTICLES, 1987, 111 (01) :117-122

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