GANGLIOSIDE-GM3 STIMULATES THE UPTAKE AND PROCESSING OF LOW-DENSITY LIPOPROTEINS BY MACROPHAGES

被引：19

作者：

PROKAZOVA, NV

MIKHAILENKO, IA

BERGELSON, LD

机构：

[1] Institute of Experimental Cardiology, Cardiology Research Center, the USSR Academy of Medical Sciences, Moscow

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 177卷 / 01期

关键词：

D O I：

10.1016/0006-291X(91)92023-D

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Preincubation of low densiy lipoproteins (LDL) with low concentrations of the ganglioside GM3 (1-2× 10-5 M/ 2.5×10-6 M LDL-protein) results in an increase of LDL-uptake, enhances cholesterol accumulation and cholesteryl ester formation by macrophages. At the same time the lysosomal degradation of LDL in macrophages was inhibited under these conditions. These effects depended on the ganglioside structure and concentration. It is suggested that the effects observed could be caused by GM3-induced modification of LDL to a form that becomes recognized by macrophages. © 1991.

引用

页码：582 / 587

页数：6

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