4-N-AMINOACYLFORTIMICINS-E

被引:12
作者
KURATH, P [1 ]
GRAMPOVNIK, D [1 ]
TADANIER, J [1 ]
MARTIN, JR [1 ]
EGAN, RS [1 ]
STANASZEK, RS [1 ]
CIROVIC, M [1 ]
WASHBURN, WH [1 ]
HILL, P [1 ]
DUNNIGAN, DA [1 ]
LEONARD, JE [1 ]
JOHNSON, P [1 ]
GOLDSTEIN, AW [1 ]
机构
[1] ABBOTT LABS,DEPT ANALYT RES,N CHICAGO,IL 60064
关键词
D O I
10.7164/antibiotics.32.884
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The conversion of fortimicin E, a minor metabolite from the Micromonospora olivoasterospora fermentation which also produces fortimicin A and fortimicin B, to four 4-N-aminoacyl-fortimicins E was accomplished. The new 4-N-aminoacylfortimicins E showed only weak antimicrobial activity against several Gram-negative and Gram-positive microorganisms. © 1979, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.
引用
收藏
页码:884 / 890
页数:7
相关论文
共 15 条
[1]   N-HYDROXYSUCCINIMIDE ESTERS IN PEPTIDE SYNTHESIS [J].
ANDERSON, GW ;
ZIMMERMAN, JE ;
CALLAHAN, FM .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1963, 85 (19) :3039-&
[2]   USE OF ESTERS OF N-HYDROXYSUCCINIMIDE IN PEPTIDE SYNTHESIS [J].
ANDERSON, GW ;
CALLAHAN, FM ;
ZIMMERMAN, JE .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1964, 86 (09) :1839-+
[3]  
COOPER D J, 1971, Pure and Applied Chemistry, V28, P455, DOI 10.1351/pac197128040455
[4]   GENTAMICIN ANTIBIOTICS .4. SOME CONDENSATION PRODUCTS OF GENTAMICIN-C2 WITH AROMATIC AND ALIPHATIC ALDEHYDES [J].
COOPER, DJ ;
WEINSTEIN, J ;
WAITZ, JA .
JOURNAL OF MEDICINAL CHEMISTRY, 1971, 14 (11) :1118-+
[5]   GENTAMICIN ANTIBIOTICS .1. STRUCTURE AND ABSOLUTE STEREOCHEMISTRY OF METHYL GAROSAMINIDE [J].
COOPER, DJ ;
YUDIS, MD .
JOURNAL OF THE CHEMICAL SOCIETY C-ORGANIC, 1971, (05) :960-&
[6]   GENTAMICIN DERIVATIVES MODIFIED AT 2''-POSITION - PREPARATION OF 2''EPI-GENTAMICIN C1 AND 2''-DEOXYGENTAMICIN C2 [J].
DANIELS, PJL ;
WEINSTEIN, J ;
TKACH, RW ;
MORTON, J .
JOURNAL OF ANTIBIOTICS, 1974, 27 (02) :150-154
[7]   FORTIMICINS-A AND FORTIMICINS-B, NEW AMINOGLYCOSIDE ANTIBIOTICS .3. STRUCTURAL IDENTIFICATION [J].
EGAN, RS ;
STANASZEK, RS ;
CIROVIC, M ;
MUELLER, SL ;
TADANIER, J ;
MARTIN, JR ;
COLLUM, P ;
GOLDSTEIN, AW ;
DEVAULT, RL ;
SINCLAIR, AC ;
FAGER, EE ;
MITSCHER, LA .
JOURNAL OF ANTIBIOTICS, 1977, 30 (07) :552-563
[8]  
EGAN RS, UNPUBLISHED
[9]  
FUJINO M, 1974, CHEM PHARM BULL, V22, P1857
[10]  
IRVINE JC, 1922, J CHEM SOC, P2376