DIRECT VISUALIZATION OF SEROTONIN(1D) RECEPTORS IN THE HUMAN BRAIN USING A NEW IODINATED RADIOLIGAND

被引：27

作者：

PALACIOS, JM ^{[1
]}

WAEBER, C ^{[1
]}

BRUINVELS, AT ^{[1
]}

HOYER, D ^{[1
]}

机构：

[1] SANDOZ PHARMA LTD, PRECLIN RES, BASEL, SWITZERLAND

来源：

MOLECULAR BRAIN RESEARCH | 1992年 / 13卷 / 1-2期

关键词：

SEROTONIN-5-O-CARBOXYMETHYL-GLYCYL[I-125]TYROSINAMIDE; SUBSTANTIA-NIGRA; GLOBUS PALLIDUS; H-3]SEROTONIN BINDING SITE;

D O I：

10.1016/0169-328X(92)90060-O

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The development of the new ligand serotonin-5-O-carboxymethyl-glycyl [I-125]tyrosinamide (abbreviated [I-125]GTI) allows for the direct visualization of serotonin1B and serotonin1D (5-HT1B/1D) sites. Autoradiographic techniques were used to demonstrate the selective binding of this ligand to 5-HT1D sites in human post-mortem brain materials. The distribution of [I-125]GTI binding sites was compared to [H-3]5-HT sites in the presence of different displacers. The results show the selective binding of [I-125]GTI to sites in the basal ganglia and substantia nigra which corresponds to 5-HT1D receptors.

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页码：175 / 179

页数：5

相关论文

共 12 条

[1] A NEW 5-HYDROXY-INDOLE DERIVATIVE WITH PREFERENTIAL AFFINITY FOR 5-HT1B BINDING-SITES [J].

BOULENGUEZ, P ;

CHAUVEAU, J ;

SEGU, L ;

MOREL, A ;

LANOIR, J ;

DELAAGE, M .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1991, 194 (01) :91-98

[2] HOMOGENEOUS 5-HT1D RECOGNITION SITES IN THE HUMAN SUBSTANTIA-NIGRA IDENTIFIED WITH A NEW IODINATED RADIOLIGAND [J].

BRUINVELS, AT ;

LANDWEHRMEYER, B ;

WAEBER, C ;

PALACIOS, JM ;

HOYER, D .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1991, 202 (01) :89-91

[3] DIFFERENTIAL MODULATION OF 5-HYDROXYTRYPTAMINE1D BINDING-SITES BY GTP AND GTPGAMMAS [J].

HARRINGTON, MA ;

PEROUTKA, SJ .

BRAIN RESEARCH, 1990, 506 (01) :172-174

[4] DETECTION OF A NOVEL SEROTONIN RECEPTOR SUBTYPE (5-HT1E) IN HUMAN-BRAIN - INTERACTION WITH A GTP-BINDING PROTEIN [J].

LEONHARDT, S ;

HERRICKDAVIS, K ;

TITELER, M .

JOURNAL OF NEUROCHEMISTRY, 1989, 53 (02) :465-471

[5]

LOWTHER S, 1991, BRIT J PHARMACOL, V102, pP246

[6]

PALACIOS JM, 1990, ANN NY ACAD SCI, V600, P36

[7] SEROTONIN RECEPTORS IN THE HUMAN-BRAIN .4. AUTORADIOGRAPHIC MAPPING OF SEROTONIN-2 RECEPTORS [J].

PAZOS, A ;

PROBST, A ;

PALACIOS, JM .

NEUROSCIENCE, 1987, 21 (01) :123-139

[8] SEROTONIN RECEPTOR FAMILIES IN THE CENTRAL-NERVOUS-SYSTEM - AN OVERVIEW [J].

PEROUTKA, SJ ;

SCHMIDT, AW ;

SLEIGHT, AJ ;

HARRINGTON, MA .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1990, 600 :104-113

[9] SEROTONIN-1 RECEPTOR-BINDING SITES IN THE HUMAN BASAL GANGLIA ARE DECREASED IN HUNTINGTONS-CHOREA BUT NOT IN PARKINSONS-DISEASE - A QUANTITATIVE INVITRO AUTORADIOGRAPHY STUDY [J].

WAEBER, C ;

PALACIOS, JM .

NEUROSCIENCE, 1989, 32 (02) :337-347

[10] THE SEROTONIN 5-HT1D RECEPTOR - A PROGRESS REVIEW [J].

WAEBER, C ;

SCHOEFFTER, P ;

HOYER, D ;

PALACIOS, JM .

NEUROCHEMICAL RESEARCH, 1990, 15 (06) :567-582