INDUCTION OF CHROMOSOME-ABNORMALITIES IN MOUSE AND HUMAN EPIDERMAL-KERATINOCYTES BY THE HUMAN PAPILLOMAVIRUS TYPE-16 E7-ONCOGENE

被引：85

作者：

HASHIDA, T

YASUMOTO, S

机构：

[1] Lab of Molecular Biology, Kanagawa Cancer Center, Asahi-ku, Yokohama 241

来源：

JOURNAL OF GENERAL VIROLOGY | 1991年 / 72卷

关键词：

INDUCED MALIGNANT TRANSFORMATION; RETINOBLASTOMA GENE-PRODUCT; RAT; 3Y1; CELLS; SV40-TRANSFORMED CELLS; CYTOGENETIC ANALYSIS; CERVICAL-CARCINOMA; ACTIVATED RAS; TUMOR-ANTIGEN; E7; PROTEIN; DNA;

D O I：

10.1099/0022-1317-72-7-1569

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Cytogenetic abnormalities associated with human papillomavirus (HPV) type 16 were studied using primary human and mouse epidermal keratinocytes. The E7 transforming gene of HPV-16 was found to induce chromosome duplication in epidermal keratinocytes; little or no detectable chromosome disorganization was associated with the function of the E6 gene. These results suggest that the E7 gene-linked cytogenetic effect reflects HPV-16-associated pathogenicity in the early phase of transformation.

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页码：1569 / 1577

页数：9

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