NITROGEN-DIOXIDE EXPOSURE AND URINARY-EXCRETION OF HYDROXYPROLINE AND DESMOSINE

被引：12

作者：

ADGATE, JL ^{[1
]}

REID, HF ^{[1
]}

MORRIS, R ^{[1
]}

HELMS, RW ^{[1
]}

BERG, RA ^{[1
]}

HU, PC ^{[1
]}

CHENG, PW ^{[1
]}

WANG, OL ^{[1
]}

MUELENAER, PA ^{[1
]}

COLLIER, AM ^{[1
]}

HENDERSON, FW ^{[1
]}

机构：

[1] UNIV N CAROLINA, CHAPEL HILL, NC 27514 USA

来源：

ARCHIVES OF ENVIRONMENTAL HEALTH | 1992年 / 47卷 / 05期

关键词：

D O I：

10.1080/00039896.1992.9938378

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The relationship between average and peak personal exposure to nitrogen dioxide and urinary excretion of hydroxyproline and desmosine was investigated in a population of preschool children and their mothers. Weekly average personal nitrogen dioxide exposures for subjects who resided in homes with one or more potential nitrogen dioxide source (e.g., a kerosene space heater, gas stove, or tobacco smoke) ranged between 16.3 and 50.6 ppb (30.6 and 95.1 mug/m3) for children and between 16.9 and 44.1 ppb (12.8 and 82.9 mug/m3) for mothers. In these individuals, the hydroxyproline-to-creatinine and desmosine-to-creatinine ratios were unrelated to personal nitrogen dioxide exposure-even though continuous monitoring documented home nitrogen dioxide concentration peaks of 100-475 ppb lasting up to 100 h in duration. Significantly higher hydroxyproline-to-creatinine and desmosine-to-creatinine ratios were observed in children, compared with mothers (p < .001 and .003, respectively).

引用

页码：376 / 384

页数：9

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