A DROSOPHILA-MELANOGASTER HOMOLOG OF THE T-CELL ONCOGENE HOX11 LOCALIZES TO A CLUSTER OF HOMEOBOX GENES

被引：17

作者：

DEAR, TN ^{[1
]}

RABBITTS, TH ^{[1
]}

机构：

[1] MRC,MOLEC BIOL LAB,CAMBRIDGE CB2 2QH,ENGLAND

来源：

GENE | 1994年 / 141卷 / 02期

关键词：

CDNA; TRANSLOCATION;

D O I：

10.1016/0378-1119(94)90576-2

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The human homeobox gene HOX11 has been identified at the site of a chromosomal translocation in a subset of T-cell acute leukaemias. In the mouse genome, the hox11 family consists of at least three related genes, each of which possesses a highly conserved homeobox. To assist in elucidating the roles of this gene, a homologue was studied from Drosophila melanogaster. This gene, 311, shares similar identity to all three murine family members and contains the threonine residue in helix 3 of the homeodomain characteristic of the Hox11 family. It maps to a cluster of NK-homeobox genes which function in muscle development. Gene 311 exhibits a similar temporal pattern of expression to the NK genes in this cluster. Therefore, 311 may constitute part of a homeobox cluster in which the genes are both co-ordinately regulated and functionally related.

引用

页码：225 / 229

页数：5

共 21 条

[1] ASHBURNER M, 1989, DROSOPHILA LABORATOR
[2] SEGMENTS OF THE POU DOMAIN INFLUENCE ONE ANOTHERS DNA-BINDING SPECIFICITY
AURORA, R
HERR, W
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1992, 12 (02) : 455 - 467
[3] BODMER R, 1990, DEVELOPMENT, V110, P661
[4] THE MECHANISM OF CHROMOSOMAL TRANSLOCATION T(11-14) INVOLVING THE T-CELL RECEPTOR C-DELTA LOCUS ON HUMAN-CHROMOSOME 14Q11 AND A TRANSCRIBED REGION OF CHROMOSOME 11P15
BOEHM, T
BAER, R
LAVENIR, I
FORSTER, A
WATERS, JJ
NACHEVA, E
RABBITTS, TH
[J]. EMBO JOURNAL, 1988, 7 (02) : 385 - 394
[5] ACUTE LEUKEMIAS OF DIFFERENT LINEAGES HAVE SIMILAR MLL GENE FUSIONS ENCODING RELATED CHIMERIC PROTEINS RESULTING FROM CHROMOSOMAL TRANSLOCATION
CORRAL, J
FORSTER, A
THOMPSON, S
LAMPERT, F
KANEKO, Y
SLATER, R
KROES, WG
VANDERSCHOOT, CE
LUDWIG, WD
KARPAS, A
POCOCK, C
COTTER, F
RABBITTS, TH
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (18) : 8538 - 8542
[6] THE HOX11 GENE ENCODES A DNA-BINDING NUCLEAR TRANSCRIPTION FACTOR BELONGING TO A DISTINCT FAMILY OF HOMEOBOX GENES
DEAR, TN
SANCHEZGARCIA, I
RABBITTS, TH
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (10) : 4431 - 4435
[7] MOLECULAR-CLONING OF PUTATIVE ODORANT-BINDING AND ODORANT-METABOLIZING PROTEINS
DEAR, TN
CAMPBELL, K
RABBITTS, TH
[J]. BIOCHEMISTRY, 1991, 30 (43) : 10376 - 10382
[8] A NEW DROSOPHILA HOMEO BOX GENE IS EXPRESSED IN MESODERMAL PRECURSOR CELLS OF DISTINCT MUSCLES DURING EMBRYOGENESIS
DOHRMANN, C
AZPIAZU, N
FRASCH, M
[J]. GENES & DEVELOPMENT, 1990, 4 (12A) : 2098 - 2111
[9] DUBE ID, 1991, BLOOD, V78, P2996
[10] RAPID PRODUCTION OF FULL-LENGTH CDNAS FROM RARE TRANSCRIPTS - AMPLIFICATION USING A SINGLE GENE-SPECIFIC OLIGONUCLEOTIDE PRIMER
FROHMAN, MA
DUSH, MK
MARTIN, GR
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (23) : 8998 - 9002

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