SYNTHESIS AND ANTI-VIRAL ACTIVITY OF 5-[(CYANOMETHYLENE)OXY]-2'-DEOXYURIDINE

被引：7

作者：

HUANG, GF

OKADA, M

DECLERCQ, E

TORRENCE, PF

机构：

[1] NIAMDD,CHEM LAB,BETHESDA,MD 20205

[2] TOKYO BIOCHEM RES INST,TOSHIMA KU,TOKYO,JAPAN

[3] CATHOLIC UNIV LEUVEN,REGA INST,B-3000 LOUVAIN,BELGIUM

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1981年 / 24卷 / 04期

关键词：

D O I：

10.1021/jm00136a007

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：390 / 393

页数：4

共 26 条

[21]

ROYBURMAN S, 1966, J BIOL CHEM, V241, P781

[22] SYNTHESIS OF 5-[(METHYLTHIO)METHYL]-2'-DEOXYURIDINE, THE CORRESPONDING SULFOXIDE AND SULFONE, AND THEIR 5'-PHOSPHATES - ANTI-VIRAL EFFECTS AND THYMIDYLATE SYNTHETASE INHIBITION [J].

SCHMIDT, CL ;

CHANG, CTC ;

DECLERCQ, E ;

DESCAMPS, J ;

MERTES, MP .

JOURNAL OF MEDICINAL CHEMISTRY, 1980, 23 (03) :252-256

[23]

SHEPPARD HA, 1970, CHEM CYANO GROUP, P209

[24]

SILVERSTEIN RM, 1974, SPECTROMETRIC IDENTI, P110

[25] 5-O-ALKYLATED DERIVATIVES OF 5-HYDROXY-2'-DEOXYURIDINE AS POTENTIAL ANTI-VIRAL AGENTS - ANTI-HERPES ACTIVITY OF 5-PROPYNYLOXY-2'-DEOXYURIDINE [J].

TORRENCE, PF ;

SPENCER, JW ;

BOBST, AM ;

DESCAMPS, J ;

DECLERCQ, E .

JOURNAL OF MEDICINAL CHEMISTRY, 1978, 21 (02) :228-231

[26] IMPROVED SYNTHESIS AND INVITRO ANTIVIRAL ACTIVITIES OF 5-CYANOURIDINE AND 5-CYANO-2'-DEOXYURIDINE [J].

TORRENCE, PF ;

BHOOSHAN, B ;

DESCAMPS, J ;

DECLERCQ, E .

JOURNAL OF MEDICINAL CHEMISTRY, 1977, 20 (07) :974-976

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